正交试验优化杏贝止咳提取物的微波干燥工艺  

Microwave drying technology optimization of Xingbei Zhike extract by orthogonal test

作　　者：周茆[1,2,3] 石晓朦 王正宽[1,2,3] 王振中[1,2,3] 萧伟[1,2,3] 

机构地区：[1]江苏康缘药业股份有限公司,江苏连云港222047 [2]中药制药过程新技术国家重点实验室,江苏连云港222047 [3]中药提取精制新技术重点研究室,江苏连云港222047

出　　处：《现代药物与临床》2016年第2期143-147,共5页Drugs & Clinic

基　　金：国家重大新药创制科技重大专项(2013ZX09402203)

摘　　要：目的优化杏贝止咳提取物的微波干燥工艺参数。方法以苦杏仁苷、白花前胡甲素和白花前胡乙素综合转移率为考察指标,选取微波功率、干燥时间、铺盘厚度、真空度作为优化试验考察因素,每个因素设计3个水平,采用L9(34)正交试验优化杏贝止咳浸膏的微波干燥工艺,并与常规干燥工艺进行比较。结果杏贝止咳浸膏最佳微波干燥工艺为微波功率6k W,干燥时间9 min,铺盘厚度2~2.5 cm,真空度-0.08^-0.09 MPa。结论该工艺高效节能,稳定可行,为改善杏贝止咳颗粒的干燥工艺提供实验依据。Objective To optimize microwave drying technology parameters of Xingbei Zhike extract by orthogonal test. Methods Comprehensive transfer rates of amygdalin, praeruptorin A, and praeruptorin B were used as index, microwave power supply. The drying time, the shop disc thickness, and the vacuum degree were selected as main factors, and every factor had three levels. L9（34） orthogonal test was used to optimize microwave drying process for Xingbei Zhike extract, and the results were compared with those of the conventional drying process. Results The optimized conditions of microwave drying process for Xingbei Zhike extract were microwave power supply 6 k W, the drying time 9 min, the shop disc thickness 2 — 2.5 cm, and the vacuum degree-0.08 —-0.09 MPa. Conclusion The process is efficient and energy saving, stable,and feasible, which can provide evidences for improvement of drying for Xingbei Zhike Granules.

关 键 词：杏贝止咳提取物 微波干燥 苦杏仁苷 白花前胡甲素 白花前胡乙素 正交试验 

分 类 号：R284.2[医药卫生—中药学] R286.02[医药卫生—中医学]