陶瓷膜超滤精制金银花水提液的工艺研究  

Purification of Lonicerae Japonicae Flos water extract solution by ceramic membrane ultrafiltration

作　　者：武景路 王青[1] 祝帆[1] 王小南[1] 焦泽沼 赵志骞 

机构地区：[1]石家庄以岭药业股份有限公司,河北石家庄050035

出　　处：《现代药物与临床》2016年第2期148-150,共3页Drugs & Clinic

摘　　要：目的优化陶瓷膜超滤法精制金银花水提液的工艺条件。方法以金银花水提液为研究对象,绿原酸转移率为指标,选用膜孔径、料液温度、超滤压力和超滤时间4个主要因素,每个因素各选取3个水平,采用L9(34)正交试验表进行正交试验。结果最佳优化参数:膜孔径选择30 nm,料液温度选择85℃,超滤压力选择0.18 MPa,超滤时间选择60 min。结论采用陶瓷膜超滤技术对金银花水提液进行精制的渗透量大,指标性成分转移率高,为陶瓷膜在中药水提液的精制研究提供了可靠的实验依据。Objective To optimize the purification conditions of Lonicerae Japonicae Flos water extract solution by ceramic membrane ultrafiltration. Methods Lonicerae Japonicae Flos water extract solution was used as object of study, and transfer rate of chlorogenic acid was investigated as indicators. The choice of membrane pore size, ultrafiltration time, ultrafiltration pressure, and ultrafiltrate temperature were selected as main factors, and three levels were established for every factor. L9（34） orthogonal test was used to optimize purification conditions. Results The optimized conditions were as following： membrane pore size 30 nm, ultrafiltration pressure 0.18 MPa, ultrafiltration temperature 85 ℃, and ultrafiltration time 60 min. Conclusion The method of purification conditions of Lonicerae Japonicae Flos water extract solution by ceramic membrane ultrafiltration has more permeation quantity and high transfer rate on index components, which provides reliable experimental basis study on purification of Chinese herbal medicine extract by ceramic membrane.

关 键 词：金银花 陶瓷膜超滤 绿原酸 正交试验 

分 类 号：R284.2[医药卫生—中药学] R286.02[医药卫生—中医学]