超液化碘油＋PYM 混合剂＋明胶海绵微粒联合栓塞治疗巨大肝脏血管瘤的临床疗效及安全性  

Analysis of clinical curative effect and safety influence of ultra liquified lipiodol ＋PYM Mixture＋gelatin sponge particles combined with embolization on giant hepatic hemangioma

作　　者：王天玉[1] 刘俊中[1] 王海波[1] 刘一强[1] 

机构地区：[1]郑州大学附属郑州中心医院介入科,450007

出　　处：《中国实用医刊》2016年第2期40-41,共2页Chinese Journal of Practical Medicine

摘　　要：目的：观察超液化碘油＋PYM（平阳霉素）混合剂＋明胶海绵微粒联合栓塞治疗巨大肝脏血管瘤的临床疗效及安全性。方法选取2012年6月至2014年6月于郑州大学附属郑州中心医院接受治疗的60例巨大肝脏血管瘤患者作为研究对象，按照随机数字表法将其分为对照组与观察组，每组30例。观察组接受超液化碘油、PYM、明胶海绵微粒联合栓塞介入治疗方案，对照组则接受常规肝脏血管瘤切除术治疗，对比观察两组患者的治疗效果及并发症发生率。结果观察组肝巨大血管瘤缩小I级22例，Ⅱ级5例，Ⅲ级2例，Ⅳ级1例，其血管瘤整体缩小程度明显优于对照组（ P＜0.05）；观察组发生破溃出血1例，肝功能异常1例，整体并发症发生率为6.6％，明显低于对照组的36.7％，差异有统计学意义（P＜0.05）；观察组介入治疗后住院时间为（6.7±2.5）d，对照组为（10.9±1.6）d。观察组住院时间明显低于对照组（t＝7.750，P＜0.05）。结论在肝脏巨大血管瘤患者的临床治疗中，采用超液化碘油联合平阳霉素混合剂栓塞方案，并辅助使用明胶海绵颗粒进行栓塞填充，可明显优化患者的治疗效果，降低术后并发症发生率，值得推广。Objective To observe the clinical curative effect and safety of ultra liquified lipiodol ＋PYM（ Pingy-ang mycin） mixture ＋gelatin sponge particles combined with embolization in treatment of huge hepatic hemangioma . Methods Sixty cases of giant hepatic hemangioma patients from June 2012 to June 2014 in our hospital were selected as the research objects and were randomly divided into control group and observation group , with 30 cases in each group .The observation group received interventional treatment of Lipiodol , PYM, embolization with gelatin sponge particles , while the control group received the routine liver resection of hemangioma treatment , comparative observation of therapeutic effect and complications incidence of two groups .Results The giant hemangioma of liver reduced in observation group , 22 cases of grade Ⅰ, 5 cases of grade Ⅱ, 2 cases in grade Ⅲ, 1 cases of grade Ⅳ, the hemangioma wholly reduced significantly bet-ter than of control group（P〈0.05）;the observation group occurred in 1 cases of burst bleeding, 1 case of abnormal liver function, the overall complication rate was 6.6%, significantly lower than that of the control group （36.7%）, the difference was significant between the two groups （P〈0.05）.The hospitalization time after intervention in observation group was （6.7 ±2.5） d, that of the control group was （10.9 ±1.6） d.The hospitalization time in observation group was significantly lower than that in the control group （t=7.750, P〈0.05）.Conclusions In clinical treatment of huge hepatic hemangioma patients, using lipiodol embolization combined with Pingyang mycin mixture embolism scheme can significant optimize treatment effect , reduce the incidence of complication during postoperative , so it is worthy of promotion .

关 键 词：血管瘤 明胶海绵微粒 超液化碘油 介入治疗 安全性 

分 类 号：R735.7[医药卫生—肿瘤]