新疆维吾尔族、哈萨克族和汉族高血压人群维生素D水平的现况调查  

Difference of vitamin D levels in hypertensives in Xinjiang Uygur,Kazak and Han population

作　　者：徐新娟[1] 胡广梅[1] 韩璐[2] 陈玉岚[1] 李海侠[3] 

机构地区：[1]新疆医科大学第一附属医院高血压科,新疆乌鲁木齐830054 [2]新疆武警总医院心内科 [3]新疆医科大学在读研究生

出　　处：《中华高血压杂志》2015年第12期1171-1176,共6页Chinese Journal of Hypertension

基　　金：国家自然科学基金(81160038)

摘　　要：目的了解新疆维吾尔族、哈萨克族和汉族高血压患者维生素D水平的状况及民族差异性。方法采用随机抽样的方法,抽取喀什、阜康、乌鲁木齐地区的原发性高血压患者3318例（汉族1332例,维吾尔族1011例,哈萨克族975例）,采用电化学发光法检测血清25羟基维生素D[25（OH）D]浓度;血清25（OH）D〈30nmol/L为维生素D缺乏;30~〈50nmol/L为维生素D不足;≥50nmol/L为维生素D充足。结果新疆不同民族高血压患者血清25（OH）D水平存在差异,哈萨克族血清25（OH）D高于汉族,汉族血清25（OH）D高于维吾尔族[（38.05±20.02）比（35.63±18.37）比（25.45±18.67）nmol/L,均P〈0.05]。3318例高血压患者中,血清25（OH）D缺乏占50.45%,不足占31.80%,充足仅为17.75%。男性血清25（OH）D水平高于女性[（35.68±18.50）比（30.80±20.58）nmol/L,P〈0.05]。青年（〈45岁）、中年（45~〈65岁）和老年（≥65岁）组之间血清25（OH）D水平差异无统计学意义。多因素Logistic回归分析显示,25（OH）D水平与收缩压呈负相关（OR=0.912,95%CI 0.855~0.973）。结论新疆哈萨克族、维吾尔族、汉族高血压患者血清25（OH）D缺乏普遍存在,且存在民族差异性,25（OH）D水平与收缩压呈负相关。Objective To explore the difference of vitamin D levels in hypertensive population in Xinjiang Uygur,Kazak and Han. Methods A total of 3318 hypertensive inhabitants,including 1332 cases of Han,1011 cases of Uygur and 975 cases of Kazak,were selected from Kashi,Fukang and Urumqi using cluster random sampling method. Serum 25 hydroxyvitamin D[25（OH）D]concentration was detected with electrochemiluminescence immunoassay. The concentration of serum 25（OH）D30nmol/L was defined as vitamin D difficiency,30-50nmol/L as inadequacy,≥50nmol/L as sufficiency. Results There was difference on level of vitamin D in different ethnic in Xinjiang. Serum 25（OH）D level in Kazak was significantly higher than that in Han,and which in Han was significantly higher than in Uygur[（38.05±20.02）vs（35.63±18.37）vs（25.45±18.67）nmol/L;P0.05]. The percentage of vitamin D difficiency accounted for 50.45%,the inadequacy accounted for 31.80%,and the sufficiency accounted for only 17.75%in 3318 cases of hypertension patients. Serum 25（OH）D level was higher in male than in female[（35.68±18.50）vs（30.80±20.58）nmol/L]. There was no significant difference on concentration of25（OH）D in young group（45years old）,middle age group（45-65years old）and elderly group（≥65years old）. Multifactor logistic regression analysis showed that serum 25（OH）D level was negatively correlated with systolic blood pressure（OR=0.912,95% CI0.855-0.973）. Conclusion The serum 25（OH）D deficiency is common in hypertensive poputation in Xinjiang Uygur,Kazak and Han,and there is differences between ethnic groups.25（OH）D is negatively correlated with blood pressure.

关 键 词：高血压 25羟基维生素D 维吾尔族 哈萨克族 汉族 

分 类 号：R544.1[医药卫生—心血管疾病]