高压氧联合中药“蝎七方”改善急性脊髓损伤患者神经功能的临床观察  

Clinical observation on the treatment of acute spinal cord injury with hyperbaric oxygen combined with traditional herbal medicine

作　　者：吕春风[1] 李京[2] 曹锐[2] 苏庆军[4] 康南[4] 高春锦[3] 杨晶[3] 

机构地区：[1]北京航天总医院高压氧科,北京100076 [2]首都医科大学附属北京朝阳医院中医科 [3]首都医科大学附属北京朝阳医院骨科 [4]首都医科大学附属北京朝阳医院高压氧科

出　　处：《中华航海医学与高气压医学杂志》2015年第6期437-440,共4页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：国家国际科技合作专项基金（2012DFA31240）

摘　　要：目的：探讨高压氧联合中药“蝎七方”治疗对急性脊髓损伤患者美国脊髓损伤协会（ American spinal injury association ， ASIA）痛觉和运动评分、Frankel分级评分的影响，评价临床疗效。方法60例急性脊髓损伤患者，为不完全性脊髓损伤。对照组（常规＋高压氧治疗组）30例、治疗组（“蝎七方”＋高压氧治疗组）30例。对照组给予常规药物治疗，有（或无）外科手术治疗，加高压氧疗法。治疗组在常规治疗加高压氧疗法基础上，给予中药“蝎七方”口服治疗。高压氧治疗方案：治疗压力0．2 MPa，稳压吸氧时间60 min。高压氧治疗1次／d ，连续治疗30 d。中药每日服用蝎七方1．5 g（3粒）2次，餐后口服，连续服用3个月。在治疗前、治疗后第10天、30天、60天、3个月的相同时间点，观察2组患者ASIA痛觉和运动评分、Frankel分级评分，评价总有效率。结果治疗组与对照组比较， ASIA痛觉评分在治疗后第30、60、90天差异有统计学意义（ P＜0．05）；ASIA运动评分在治疗后第30、60、90天差异有统计学意义（ P＜0．01）。 Frankel总肌力评分在治疗后第30、60、90天差异有统计学意义（ P＜0．05），第10天差异有统计学意义（P＜0．01）；Frankel感觉评分在治疗后第30、60天差异有统计学意义（P＜0．05），第10、90天差异有统计学意义（P＜0．01）。治疗组总有效率为86．7％。结论高压氧结合中药“蝎七方”治疗，明显提高治疗的有效率，促进临床神经功能恢复，为中西医结合治疗急性脊髓损伤提供了临床依据。Objective To investigate the effects of hyperbaric oxygen （ HBO ） combined with herbal“scorpion seven” on the ASIA pain and motion scores and Frankel classification scores in the patients with acute spinal cord injury （ ASCI ） , and also to evaluate the clinical effects of the treatment .Methods Sixty patients with incomplete spinal cord injury were chosen for our study , and were divided into the control group （treated with conventional therapy ＋HBO） and the treatment group （treated with scorpion seven ＋HBO）. At the same time points of the 10th, 30 th, 60 th days and the third month , close observations were made on the scores of ASIA pain and motion scores and Frankel classification scores , and evaluations were also made on the total effective rate .Results Following 30, 60 and 90 days of treatment , significant differences could be seen in the Asia pain scores in the treatment group , as compared with those of the control group （P〈0.05）. There were also significant differences in ASIA motion scores after 30, 60 and 90 days of treatment, when comparisons were made between the 2 groups （P〈0.01）.There were also significant differences in Frankel total muscle scores after 30, 60 and 90 days of treatment（P〈0.05）, and significant differences could be noted＆amp;nbsp;in Frankel total muscle scores at day 10 （P〈0.01）.Significant differences could be found in Frankel sensory scores in the treatment group, following 30 and 60 days of treatment（P〈0.05）, and significant differences could also be noticed in Frankel sensory scores at day 10 and day 90（P〈0.01）.Total effective rate for the treatment group was 86.7%.Conclusions HBO combined with herbal ＆quot;scorpion seven＆quot;could significantly improve effective rate of the treatment , promote neurological function recovery clinically , and it would provide clinical evidence for the treatment of acute spinal cord injury by combining traditional herbal medicine with Western medicine .

关 键 词：高压氧 脊髓损伤 蝎七方 ASIA损伤分级 Frankel分级评分 

分 类 号：R651.2[医药卫生—外科学]