耳叶牛皮消化学成分研究  

Chemical Constituents of Cynanchum auriculatum

作　　者：何江波[1] 贾静[1] 句红萍 张雪梅[1] 缪希松[1] 何方[1] 陶剑[1] 

机构地区：[1]昆明学院医学院,云南昆明650214

出　　处：《中药材》2015年第11期2318-2320,共3页Journal of Chinese Medicinal Materials

基　　金：昆明学院博士基金启动项目(YJL14009)

摘　　要：目的：研究耳叶牛皮消的化学成分。方法：采用硅胶柱层析、反相RP-18柱色谱、Sephadex LH-20凝胶柱色谱等方法,从耳叶牛皮消中分离得到9个化合物。结果：通过NMR和MS等波谱方法结合文献数据对比,分别鉴定为：sarcosin-3-O-β-cymaropyranoside（1）、cynotophylloside B（2）、clemaphenol A（3）、去乙酰基萝苷元（4）、methyl-2,6-dideoxy-3-O-methyl-β-D-arabino-hexopyranosyl-（1→4）-6-deoxy-3-O-methyl-α-L-ribo-hexopyranoside（5）、反式对羟基桂皮酸甲酯（6）、cyclo（D-Pro-D-Leu）（7）、3α-hydroxy-5α,6α-epoxy-7-megastigmen-9-one（8）、阿魏酸甲酯（9）。结论：其中,化合物3、5、6~9为首次从该植物中分离得到。Objective： To study the chemical constituents of Cynanchum auriculatum. Methods： Nine compounds were isolated by silica gel,RP-18 column chromatography and Sephadex LH-20. Resutls： Nine compounds were isolated from the ethanol extract of Cynanchum auriculatum. Their structures were determined as sarcosin-3-O-β-cymaropyranoside（ 1）,cynotophylloside B（ 2）,clemaphenol A（ 3）,deacetylmetaplexigenin（ 4）,methyl-2,6-dideoxy-3-O-methyl-β-D-arabino-hexopyranosyl-（ 1→4）-6-deoxy-3-O-methyl-α-L-ribo-hexopyranoside（ 5）,trans-p-hydroxy cinnamic methyl ester（ 6）,cyclo（ D-Pro-D-Leu）（ 7）,3α-hydroxy-5α,6α-epoxy-7-megastigmen-9-one（ 8） and ferulic acid methyl ester（ 9） on the basis of spectral analysis. Conclusion： Compounds 3,5 and 6 ~ 9 are isolated from Cynanchum auriculatum for the first time.

关 键 词：萝藦科 耳叶牛皮消 化学成分 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]