BMP-7在子痫前期肾脏损伤中的表达及临床意义  

Expression and Significance of BMP-7 in Preeclampsia Renal Damage

作　　者：姜涛[1] 何雅静[1] 赵婷婷[1] 张翼飞[1] 张亚[1] 

机构地区：[1]长江大学附属第一医院湖北省荆州市第一人民医院妇产科,湖北荆州434000

出　　处：《现代生物医学进展》2015年第36期7091-7093,7146,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81202063)

摘　　要：目的:探究BMP-7在子痫前期肾脏损伤中的表达及临床意义。方法:选取2012年3月到2013年12月我院妇产科收治的98例子痫前期肾脏损伤患者作为研究对象,以30例健康孕妇为对照,分别采用ELISA方法检测血液、尿液中BMP-7蛋白、尿β2微球蛋白(β2-MG)浓度,以苄索氯胺比浊法测定24 h尿蛋白定量。结果:1与对照组相比,子痫前期肾脏损伤患者尿液及血清BMP-7蛋白浓度显著降低(P<0.05);2随着病程进展,子痫前期组尿液血清BMP-7蛋白浓度、尿白蛋白定量、β2-MG显著升高(P<0.05);3子痫前期组尿液、血清BMP-7蛋白浓度分别与尿白蛋白定量、β2-MG成正相关(P<0.05)。结论:子痫前期肾脏损伤患者血清BMP-7蛋白水平显著降低,可用于评估子痫前期肾脏损伤进展,对临床具有指导意义。Objective： To explore the expression and clinical significance of BMP- 7 in preeclampsia kidney damage. Methods：98 cases of patients with preeclampsia kidney damage from obstetrics and gynecology department from March 2012 to December 2013 were selected as the research object, and another 30 cases of healthy pregnant women was considered as controls. The concentration of serum and urine BMP- 7 protein and beta 2 microglobulin（β2-MG） in urine was detected by ELISA, 24 h urine protein quantitative determination was performed with benzyl cable chloramine turbidimetry. Results： 1Compared with control group, the concentration of urine and serum BMP 7 protein in the preeclampsia group was decreased significantly（P〈0.05）; 2With the progression of disease, the concentration of urine and serum BMP 7 protein, the quantity of urine albumin of β2-MG was significantly increased in preeclampsia group（P〈0.05）; 3the concentration of urine and serum BMP 7 protein in preeclampsia group was respectively positively correlated with quantity of urinary albumin and β2-MG（P〈0.05）. Conclusions： The serum BMP 7 protein is significantly reduced in the patients with preeclampsia renal damage, which can be used to evaluate the progress of preeclampsia renal damage, and provide guidance for clinic.

关 键 词：BMP-7 子痫前期 肾脏损伤 

分 类 号：R714.258[医药卫生—妇产科学]