甲强龙对重型颅脑损伤患者血清IL-1β和TNF-α表达的影响  

Effect of Methylprednisolone on the Levels of IL-1β and TNF-α in Serum of Patients with Severe Craniocerebral Injury

作　　者：吕卫群[1] 周路遥[1] 赵懿清[1] 高秋芳[1] 王生[1] 

机构地区：[1]无锡市第三人民医院药学部,江苏无锡214041

出　　处：《现代生物医学进展》2015年第36期7094-7097,共4页Progress in Modern Biomedicine

基　　金：江苏省自然科学基金项目(BK2010419)

摘　　要：目的:探讨甲强龙对重型颅脑损伤患者血清中白细胞介素-1β(IL-1β)及肿瘤坏死因子-α(TNF-α)的表达影响。方法:收集我院神经外科以重型颅脑损伤为诊断收治入院的患者68例,并将其随机分为实验组和对照组。实验组予以甲强龙治疗,对照组则给予地塞米松治疗,同时两组均予以利尿、降颅压、抗感染、抑酸、营养支持等常规对症支持治疗。分别于治疗前、治疗后第1、3、7天进行血清IL-1β和TNF-α水平测定,并于治疗3个月后按GOS预后评分标准进行预后评估。结果:1与治疗前比较,治疗后1天IL-1β水平及TNF-α水平较高(P<0.05),第3、7天IL-1β水平及TNF-α水平较低(P<0.05)。与对照组同期比较,实验组第1天IL-1β水平及TNF-α水平较高(P<0.05),第3、7天IL-1β水平及TNF-α水平较低(P<0.05),2治疗后实验组死亡率明显低于对照组,差异有统计学意义(P<0.05)。结论:甲强龙可显著改善重型颅脑损伤患者的预后,这可能与其抑制血清IL-1β和TNF-α的表达有关。Objective： To investigate the effect of Methylprednisolone on the IL-1β and TNF-α levels in serum of patients with severe craniocerebral injury. Method： 68 cases of patients with severe craniocerebral injury from our hospital were selected and randomly divided into the control group and the experimental group. The experimental group was treated by Methylprednisolone and the control group was treated by dexamethasone. Both groups were treated by the routine treatment of symptoms, such as diuretic, reducing intracranial pressure, anti infection, anti acid, nutritional support and so on. The serum levels of IL-1 and TNF-α were tested before treatment and 1, 3, 7 days after treatment. The prognosis was assessed by GOS score after 3 months of treatment. Results： Compared with before treatment, the IL-1β level and TNF-α level were higher on the 1st day after treatment（P〈0.05）, the IL-1β level and TNF-α level were lower on the 3rd, 7th day after treatment（P〈0.05）. Compared with the control group, the IL-1β level and TNF-α level were higher on the 1st day after treatment（P〈0.05）, the IL-1β level and TNF-α level were lower on the 3rd, 7th day after treatment（P〈0.05）.Compared with the control group after treatment, the death rate was significantly lower in the experimental group（P〈0.05）. Conclusion：Methylprednisolone could improve the prognosis of patients with severe craniocerebral injury, which might be related to the decrease of serum IL-1β and TNF-α levels.

关 键 词：甲强龙 重型颅脑损伤 白细胞介素-1Β 肿瘤坏死因子-α 

分 类 号：R651.1[医药卫生—外科学]