重症肺炎患者干扰素-γ、IL-6和TNF-α含量变化研究  

Study on the Changes of Interferon-γ, IL-6 and TNF-α of Patients with Severe Pneumonia

作　　者：刘玲[1] 赵弘卿[1] 王昕华[1] 许坤[1] 王洵[1] 

机构地区：[1]南京医科大学附属无锡市第二人民医院呼吸科,江苏无锡214002

出　　处：《现代生物医学进展》2015年第36期7107-7110,共4页Progress in Modern Biomedicine

基　　金：江苏省自然科学基金项目(BK2012606)

摘　　要：目的:探究重症肺炎患者干扰素-γ、白细胞介素-6和肿瘤坏死因子-α含量变化及其临床意义。方法:选取我院收治并确诊为肺炎的患者103例,根据病情不同,将其分为重症肺炎组52例及普通肺炎组51例,同时选取同期参加健康体检人群50例,为对照组。比较三组成员不同时间段干扰素-γ、白细胞介素-6和肿瘤坏死因子-α含量,重症肺炎组患者存活与死亡组上述因子含量情况。结果:入院6 h后,与对照组比较,重症肺炎及普通肺炎组干扰素-γ、白细胞介素-6及肿瘤坏子因子-α含量较高P<0.05,与普通肺炎组比较,重症肺炎组重症肺炎组干扰素-γ、白细胞介素-6及肿瘤坏子因子-α含量较高P<0.05;入院24 h后,与对照组比较,重症肺炎组干扰素-γ、白细胞介素-6及肿瘤坏子因子-α含量较高P<0.05,普通肺炎组与对照组比较无差异P>0.05;重症肺炎死亡组患者干扰素-γ、白细胞介素-6及肿瘤坏子因子-α含量较高P<0.05。结论:干扰素-γ、白细胞介素-6以及肿瘤坏死因子-α参与患者的免疫调节,可间接提示患者的病程发展,可作为判断病情程度的有利依据。Objective： To explore the changes of Interferon-γ, IL-6 and TNF-α of patients with Severe Pneumonia. Methods：103patients who were diagnosed with pneumonia were selected and divided into severe pneumonia group and normal pneumonia group according to different condition. 50 cases of healthy people were selected to be the control group. Interferon- γ, IL-6 and TNF-α were detected and the death rate and survival rate were compared after the treatment. Results： Compared with the control group after 6h,interferon- gamma, leukocyte interleukin- 6 and tumor necrosis factor alpha of the severe pneumonia and normal pneumonia was higher P〈0.05, compared with the normal pneumonia group,the interferon- gamma, leukocyte interleukin- 6 and tumor necrosis factor alpha of the severe pneumonia and normal pneumonia was higher P〈0.05.Compared with the control group after 24 h, interferon- gamma,leukocyte interleukin- 6 and tumor necrosis factor alpha of the severe pneumonia were higher P〈0.05, There was no difference between the normal group and the control group P〈0.05;Interferon gamma, interleukin-6 and tumor necrosis factor alpha in patients with severe pneumonia were higher than that of tumor necrosis factor P〈0.05. Conclusion： Interferon gamma, interleukin-6 and tumor necrosis factor alpha in patients with immune regulation, can be indirectly prompted the development of the disease, can be used as a favorable basis for judging the degree of disease.

关 键 词：重症肺炎 干扰素-Γ 白细胞介素-6 肿瘤坏死因子-α 

分 类 号：R563[医药卫生—呼吸系统]