Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice  

作　　者：夏冬 刘冰 栾希英 孙军燕 刘娜娜 秦松 杜振宁 

机构地区：[1]School of Pharmacy, Yantai University [2]Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai institute of Coastal Zone Research, Chinese Academy of Sciences [3]School of Basic Medical, Binzhou Medical University

出　　处：《Chinese Journal of Oceanology and Limnology》2016年第2期399-404,共6页中国海洋湖沼学报（英文版）

基　　金：Supported by the National Special Research Fund for Non-Profit Marine Sector(No.201205027);the Taishan Scholar Program of Shandong Province

摘　　要：Excessive alcohol consumption leads to liver disease. Extensive evidence suggests that C-phycocyanin(C-PC), a chromophore phycocyanobilin derived from Spirulina platensis, exerts protective eff ects against chemical-induced organ damage. In this study, we investigated whether C-PC could protect against ethanol-induced acute liver injury. Serum alanine aminotransferase(ALT), aspartate aminotransferase(AST), triglyceride(TG), total cholesterol(CHOL), low-density lipoprotein(LDL), liver homogenate malondialdehyde(MDA), superoxide dismutase(SOD) content were measured, and pathological examination of liver sections were examined. C-PC showed obvious inhibitory eff ects on serum ALT, AST, TG, CHOL, LDL and MDA, and SOD content significantly increased in the liver. The structure of hepatic lobules was clear, liver sinus returned to normal, and liver cell cords were arranged in neat rows. Cloudiness, swelling, inflammatory cell infiltration and spotty necrosis of liver cells were significantly reduced. Therefore, C-PC can significantly protect against ethanol-induced acute liver injury.Excessive alcohol consumption leads to liver disease. Extensive evidence suggests that C-phycocyanin （C-PC）, a chromophore phycocyanobilin derived from Spirulina platensis, exerts protective effects against chemical-induced organ damage. In this study, we investigated whether C-PC could protect against ethanol-induced acute liver injury. Serum alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, triglyceride （TG）, total cholesterol （CHOL）, low-density lipoprotein （LDL）, liver homogenate malondialdehyde （MDA）, superoxide dismutase （SOD） content were measured, and pathological examination of liver sections were examined. C-PC showed obvious inhibitory effects on serum ALT, AST, TG, CHOL, LDL and MDA, and SOD content significantly increased in the liver. The structure of hepatic lobules was clear, liver sinus returned to normal, and liver cell cords were arranged in neat rows. Cloudiness, swelling, inflammatory cell infiltration and spotty necrosis of liver cells were significantly reduced. Therefore, C-PC can significantly protect against ethanol-induced acute liver injury.

关 键 词：C-PHYCOCYANIN acute ethanol liver injury protective effect 

分 类 号：R285.5[医药卫生—中药学]