基于MRM的小鼠脑模板创建的研究进展  

Recent Advances in the Research of the Establishment of the MRMbased Mouse Brain Template

作　　者：付振荣[1] 林岚[1] 张柏雯 宾光宇[1] 高宏建[1] 吴水才[1] 

机构地区：[1]北京工业大学生命科学与生物工程学院,北京100124

出　　处：《中国医疗设备》2016年第2期25-30,共6页China Medical Devices

基　　金：北京市自然科学基金(7143171)资助

摘　　要：高分辨率的磁共振显微成像(MRM)技术已被广泛应用于小鼠脑神经影像学的研究之中。脑模板和脑图谱是小鼠脑神经影像学研究中不可缺少的工具,但由于小鼠大脑具有体积小、微观变化细微等特点,为脑膜板和脑图谱的建立增加了很大的困难,当今国内外大量研究都致力于如何能更好的建立不同类型的小鼠脑模板。本文首先介绍了MRM的成像原理及图像的采集方式,探讨了MRM的优化措施。之后讨论了脑模板构建过程中的一些基本元素,如模板比较、配准算法等。最后介绍了小鼠脑模板在一些脑部疾病(如阿尔茨海默病、亨廷顿氏综合症等)动物模型上的基本应用。The high resolution magnetic resource microcopy（MRM） has been widely used in mouse brain neuroimaging study. The mouth brain template and atlas are the tools essential to the mouse brain neuroimaging study. The mouth brain is characterized by its small volume and subtle microscopic changes, which creates difficulty for the establishment of the brain template and atlas. Nowadays many domestic and overseas＇ researchers have focused on setting up different kinds of mouse brain templates. This paper first introduced the imaging principle and imaging collection methods of MRM and discussed the strategies to optimize MRM. Secondly, the paper discussed basic elements of the mouse brain template construction, such as comparison of templates, data acquisition, registration algorithms, and etc. Finally, the paper introduced the fundamental application of the mouse brain template in the research and treatment of diseases such as Alzheimer＇s disease and Huntington＇s disease.

关 键 词：脑图谱 脑模板 磁共振显微成像 图像配准 

分 类 号：R318.1[医药卫生—生物医学工程]