Understanding super-enhancers  

作　　者：Hao Cheng Xiaoyang Dou Jing-Dong J.Han 

机构地区：[1]Key Laboratory of Computational Biology, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center for Genetics and Developmental Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

出　　处：《Science China(Life Sciences)》2016年第3期277-280,共4页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(31210103916;91329302 and 91519330);the Progress on CAS Strategic Priority Research Program(XDA01010303);the Instrument Developing Project of the Chinese Academy of Sciences(YZ201243);the National Basic Research Program of China(2015CB964803 and 2011CB504206)to Jing-Dong J.Han

摘　　要：Super-enhancers are defined as cluster of enhancers with dense TF binding, which can activate proximal cell-identity gene expression. Here we review the identification, func- tional significance of super-enhancers, and their relation- ships with cancer. With the current intense interests in su- per-enhancers, more super-enhancers will be defined and studied in different cell types and tissues and in different developmental and biological contexts to reveal molecular mechanisms of their functions.Super-enhancers are defined as cluster of enhancers with dense TF binding,which can activate proximal cell-identity gene expression.Here we review the identification,functional significance of super-enhancers,and their relationships with cancer.With the current intense interests in super-enhancers,more super-enhancers will be defined

关 键 词：超促进剂 基因表达 分子机制 生物环境 定义 细胞 激活 

分 类 号：R961[医药卫生—药理学]