中药及其有效成分对血小板介导功能的双向调节作用探讨  

Bidirectional regulation of traditional Chinese medicine and its active components on platelet mediated functions

作　　者：王志龙[1,2] 王淼[1,2] 华声瑜[1,2] 张鹏[1,2] 朱彦[1,2] 

机构地区：[1]天津中医药大学天津市现代中药重点实验室,天津300193 [2]天津国际生物医药联合研究院中药新药研发中心,天津300457

出　　处：《中国现代中药》2016年第2期252-258,共7页Modern Chinese Medicine

基　　金：国家自然科学基金(81274128;81202798;81303183)

摘　　要：血小板不仅是止血和血栓形成的关键因子,而且在不同的生理病理条件下对炎症和血管新生也起着重要的调节作用。中药及其有效成分对血小板介导的相关功能具有显著的双向调节作用,而中药多组分、多靶点、多层次的治疗特点是其具有双向调节作用的基础。本文从止血/血栓形成、抗炎/抑炎、促进/抑制血管新生几个方面来综述最近几年中药及其有效成分对血小板功能的双向调节作用。揭示双向调节作用这一中药独特功能的分子机制将有助于更好地指导其安全有效的临床应用。Platelets not only play an important role in hemostasis and thrombosis,but also are critically involved in other physiological and pathological events such as inflammation and angiogenesis. Chinese medicine,characterized by their multi-component,multi-target,multi-level effects,has been shown increasingly to exert significant bidirectional regulation of platelet-mediated functions. We summarize recent findings of Chinese medicine and their active components that influence opposite platelet activities, with a focus on hemostasis and thrombosis, inflammation, and angiogenesis. Uncovering the molecular mechanisms of this unique feature of Chinese medicine may provide a better guidance for its safer and more efficacious clinical application.

关 键 词：中药 血小板 血栓形成 炎症 血管新生 

分 类 号：R289.5[医药卫生—方剂学]