慢性阻塞性肺疾病患者血清脂联素水平研究的Meta分析  

Meta-analysis of the level of adiponectin in chronic obstructive pulmonary disease

作　　者：李志莹[1] 徐健[1] 陈济明[1] 李一禄[1] 聂莉[1] 

机构地区：[1]广东医学院附属南山医院呼吸内科,深圳518052

出　　处：《中国综合临床》2016年第2期142-145,共4页Clinical Medicine of China

摘　　要：目的探讨血清脂联素在COPD中的临床意义。方法计算机检索Cochrane Library、PubMed、Embase、中国学术期刊全文数据库（CNKI）、维普数据库、万方数据库并手工检索相关期刊，全面收集检测COPD患者血清脂联素的病例对照研究，按照纳入、排除标准选择试验并评价质量，而后提取有效数据进行Meta分析。结果最终纳入7篇文献，其中外文2篇、中文5篇。Meta分析结果显示急性加重期COPD组血清脂联素水平明显高于COPD组，其差异有统计学意义[标准化均数差=2．32，95％C10．62-4．02，P〈0．05]。COPD组血清脂联素明显高于正常对照组，其差异有统计学意义[标准化均数差=1．39，95％CI1．00-1．78，P〈0．01]。通过Begg’s和Egger’s检验判断发表偏倚，结果未见任何偏倚（P均〉0．05）。结论COPD患者血清脂联素明显增高，检测脂联素在一定程度上能反映COPD病情。Objective To investigate the clinical significance of the level of adiponectin （APN） in patients with chronic obstructive pulmonary disease（COPD） . Methods The case-control study involving APN in OSAHS were searched and identified from Cochrane Library, PubMed, Embase, China Academic Journals Full-text database, VIP Database, and Full text database of China＇ s. According to inclusion and exclusion criteria, evaluated the quality of choice experiment, and then extracted the valid data for recta-analysis. Results Seven articles were selected, including 2 in SCI, 5 in Chinese. Meta analysis showed that APN in acute exacerbation COPD group was significantly higher than in COPD group （standardized mean difference （SMD） = 2. 32, 95%CI= 0. 62-4. 02, P〈0. 05） . Compared with normal control group, APN in COPD was higher （ SMD = 1.39, 95% CI = 1.00-1.78, P〈 0. 01 ） . Determined publication bias by Begg＇s and Egger＇s test, the results did not show any bias （P〉 0.05） . Conclusion The serum APN of COPD patients are significantly elevated, the APN testing in some extent reflect the severity of COPD.

关 键 词：慢性阻塞性肺疾病 脂联素 META分析 

分 类 号：R195.1[医药卫生—卫生统计学]