亚低温治疗对缺血缺氧息儿血清二胺氧化酶水平及胃肠功能评分的影响  

The influences of DAO and SNGF in the treatment of hypothermia for neonates after birth asphyxia

作　　者：姚爱敏[1] 李建玲[1] 夏丽娟[2] 姚亮[1] 王叶青[1] 杨红静 

机构地区：[1]保定市妇幼保健院新生儿科,河北省保定071000 [2]河北省易县疾病预防控制中心,074299 [3]河北省曲阳县人民医院儿科,073100

出　　处：《中国基层医药》2016年第3期387-390,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察选择性头部亚低温治疗对缺血缺氧患儿血清二胺氧化酶（DAO）水平及胃肠功能评分（SNGF）的影响。方法选取重度窒息患儿60例，随机分为常规治疗组和亚低温治疗组各30例，分别在入院时、人院7d采集静脉血，应用ELISA法检测DAO水平；同时比较两组患儿同时间点的SNGF评分。结果入院时，常规治疗组和亚低温治疗组DAO水平比较及SNGF评分比较差异均无统计学意义（均P〉0．05）；治疗7d后，两组DAO均下降[（12．51±1．53）u／mL比（7．88±1．87）u／mL]，但亚低温治疗组明显低于常规治疗组，差异有统计学意义（P=0．011）；两组SNGF评分均减少，而亚低温治疗组明显低于常规治疗组，差异有统计学意义（P=0．044、0．006、0．013）。血清DAO水平与SNGF评分呈显著正相关（r1=0．825，r2=0．876，均P〈0．05）。结论亚低温治疗可降低血清DAO水平，减轻窒息新生儿胃肠道的损伤，进而改善患儿胃肠功能。Objective To study the changes of diamine oxidase （DAO） levels in neonates with hypoxic - is- chemic encephalopathy （HIE） treated with selective brain hypothermi, also to further evaluate Scores for Newborn Gastrointestinal Funetior （SNGF）. Methods 60 newborns with moderate and severe HIE who were in the NICU of our department from June 2013 to December 2014 were collected. The 60 newborns were randomly divided into hypo- thermia treatment group （HG） and conventional treatment group（CG）. The serum was collected and ELISA method was used to test the consistency of DAO on admission and 7 days afterwards, respectively. Meanwhile, the SNGF level of the two groups at the two time points was compared. Results Neither the DAO and SNGF level of the two groups had statistical difference on admission（ all P 〉 0.05 ）. Seven days later, both the DAO of the two groups and the SNGF decreased[ （ 12.51 ± 1.53 ） u/mL vs （7.88 ± 1.87 ） u/mL,however,the variation of the hypothermia treatment group was apparently more significant than the change of the conventional treatment group（ P = 0. 011 ）. The SNGF scores of the two groups all decreased, while the hypothermia treatment group was significantly lower than the conventional treat- ment group, the difference were statistically significant （ P = 0. 044, 0. 006, 0. 013 ）. Besides, there was remarkably positive correlation between serum DAO level and SNGF （ rl = - 0. 825, r2 = - 0. 876, all P 〈 0.05 ）. Conclusion Hypothermia treatment could effectively reduce the injury of asphyxia neonatal gastrointestinal tract by inhibiting the level of DAO, thus improve the gastrointestinal function.

关 键 词：低温 人工 二胺氧化酶 新生儿 窒息 

分 类 号：R722.12[医药卫生—儿科]