鸢尾素-前体基因:分子结构、表达调控和生物学功能及其与骨骼肌纤维类型转化  

Irisin-Processor Gene: Molecular Structure,Expressive Regulation,Biological Functions and the Associations with Skeletal Muscle Fiber Types

作　　者：门小明[1] 陶新[1] 徐子伟[1] 

机构地区：[1]浙江省农业科学院畜牧兽医研究所,杭州310021

出　　处：《动物营养学报》2016年第2期303-311,共9页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然科学基金面上项目(31172220);国家现代农业产业技术研究体系(CARS-36);浙江省科技厅资助项目

摘　　要：鸢尾素(irisin)是新近发现的可分泌型肌源细胞因子,来源于Ⅲ型纤连蛋白组件包含蛋白5水解形成的多肽片段。目前证明鸢尾素及其前体基因在糖脂代谢疾病发生与运动治疗中发挥作用,可能与骨骼肌纤维类型转化存在关联。本文通过总结鸢尾素及其前体基因分子结构特点、表达调控和生物学功能最新研究进展,结合骨骼肌纤维类型转化机制,探讨分析鸢尾素-前体基因途径与骨骼肌纤维类型转化潜在分子关联,以期为畜禽肉质改良提供新思路。Irisin,as a novel myogenic factor,is produced by shear from fibronectin type Ⅲ domain containing protein 5（ FNDC5） and then secretes into blood circulation system. Irisin and its processor gene FNDC5 expression plays some roles on energy metabolism,obesity,diabetes and exercise therapy. This review summarized the recently research progresses about irisin and its processor gene FNDC5,majorly including their structure characteristics and physiological functions. Their molecular associations with skeletal muscle fiber types were discussed,combining the extracellular and intracellular signaling pathways mediating the conversion among different myofiber types. Our purpose was to provide some new ideas for improving pork quality through changing muscle fiber types.

关 键 词：鸢尾素 前体基因 过氧化物酶体增殖物激活受体γ辅激活因子 肉质性状 

分 类 号：S811.3[农业科学—畜牧学]