共轭聚合物在病原微生物识别、成像与杀伤中的应用研究  

The application of conjugated polymers for discrimination,imaging,and killing of pathogenic microorganism

作　　者：张江艳[1,2] 袁焕祥[1] 朱春雷[1] 刘礼兵[1] 吕凤婷[1] 王树[1] 

机构地区：[1]中国科学院化学研究所,北京100190 [2]河北大学化学与环境科学学院,保定071002

出　　处：《中国科学：化学》2016年第2期153-162,共10页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:21373243;21203213);国家重点基础研究发展计划(编号:2011CB932302;2013CB932800)资助项目

摘　　要：共轭聚合物骨架为离域电子结构,当在侧链引入正电荷基团或者选择性基团时,能与病原微生物通过静电作用或者特异性作用等结合,从而实现对不同病原微生物的识别与成像.此外,共轭聚合物还具有光毒性与暗毒性,光照下直接敏化或者通过能量转移产生活性氧,而且末端带有季铵盐基团具有广谱杀伤能力,所以共轭聚合物可用于病原微生物的杀伤.本文综述了共轭聚合物在病原微生物识别、成像与杀伤领域中的研究进展.Conjugated polymers are characterized by a delocalized electronic structure along their backbone. When introducing cationic groups or selectively-recognition elements to the side-chains,conjugated polymers can interact with pathogenic microorganism through electrostatic interactions or specific interactions,then realizing the discrimination and imaging of different pathogenic microorganism. In addition,conjugated polymers have light and/or dark killing ability. Under irradiation,conjugated polymers sensitize the production of reactive oxygen species（ROS） by either direct sensitization or indirect sensitization via energy transfer. And the quaternary ammonium terminal groups are confirmed to be capable of killing a variety of microorganisms. So conjugated polymers can be used for the killing of pathogenic microorganism. In this article,we provide a review of the application of conjugated polymers for discrimination,imaging,and killing of pathogenic microorganism.

关 键 词：共轭聚合物 病原微生物 识别 成像 杀伤 

分 类 号：R37[医药卫生—病原生物学] O631.3[医药卫生—基础医学]