A catalyst- and solvent-free multicomponent synthesis of 7-azagramine analogues via a Mannich type reaction  

作　　者：Sakharam B.Dongare Hemant V.Chavan Pravin S.Bhale Yoginath B.Mule Amol S.Kotmale Babasaheb P.Bandgar 

机构地区：[1]School of Chemical Sciences, Solapur University [2]Department of Chemistry, A.S.P.College

出　　处：《Chinese Chemical Letters》2016年第1期99-103,共5页中国化学快报（英文版）

摘　　要：A catalyst- and solvent-free protocol for the synthesis of 7-azagramine analogues is described via a three-component Mannich type reaction between 7-azaindole, aromatic aldehydes and heterocyclic amines in acceptable to excellent yields. Structures of the compounds were confirmed satisfactorily by ~1H NMR, IR, mass, TOCSY, HSQC and HMBC spectral analyses.A catalyst- and solvent-free protocol for the synthesis of 7-azagramine analogues is described via a three-component Mannich type reaction between 7-azaindole, aromatic aldehydes and heterocyclic amines in acceptable to excellent yields. Structures of the compounds were confirmed satisfactorily by ~1H NMR, IR, mass, TOCSY, HSQC and HMBC spectral analyses.

关 键 词：Bioisosters 7-Azaindole Mannich reaction Multicomponent reaction 

分 类 号：O621.3[理学—有机化学]