睡前口服二甲双胍治疗空腹血糖控制不佳的2型糖尿病患者疗效及安全性观察  

Efficacy and Safety of Metformin in the Treatment of Type 2 Diabetic Patients with Poor Fasting Blood Glucose

作　　者：解柳芸 

机构地区：[1]云南省大理州人民医院内分泌科,云南大理671000

出　　处：《糖尿病新世界》2016年第3期40-42,共3页Diabetes New World Magazine

摘　　要：目的探讨睡前口服二甲双胍治疗空腹血糖控制不佳的2型糖尿病患者效果以及安全性。方法选取2012年6月—2015年4月该院收治的空腹血糖控制不佳的2型糖尿病患者80例,随机分成两组,每组40例,观察组采用睡前口服二甲双胍联合西格列汀治疗,对照组继续西格列汀治疗,观察两组治疗效果。结果观察组患者的空腹血糖有下降且低血糖、严重低血糖以及夜间低血糖的发生次数和例数不高于对照组,差异有统计学意义(P<0.05)。结论对于空腹血糖控制不佳的2型糖尿病患者来说,在睡前口服二甲双胍是安全、有效的,能够有效降低患者的空腹血糖,且不增加低血糖、严重低血糖以及夜间低血糖的发生次数。Objective To investigate the effect and safety of oral metformin in the treatment of type 2 diabetic patients with fasting blood glucose control. Methods From June 2012 to April 2015, 2 patients with type 80 diabetes who were treated in our hospital were randomly divided into two groups, 40 cases in each group. The observation group was treated with oral metformin combined with Western treatment, and the control group was treated with the treatment of two groups. Results The fasting blood glucose of the patients in the observation group was decreased and the number of hypoglycemia, severe hypoglycemia and nocturnal hypoglycemia was not higher than that of the control group（P〈0.05）. Conclusion Oral metformin is safe and effective for patients with type 2 diabetes who are not good at fasting blood glucose control. It can effectively reduce the fasting blood glucose, and not increase the incidence of hypoglycemia, severe hypoglycemia and nocturnal hypoglycemia.

关 键 词：二甲双胍 睡前口服 空腹血糖控制不佳 2型糖尿病 效果 

分 类 号：R587[医药卫生—内分泌]