黄连素辅助治疗2型糖尿病合并幽门螺旋杆菌感染型消化性溃疡的临床疗效及安全性  

Berberine Auxiliary Treatment of Type 2 Diabetes Mellitus and Helicobacter Pylori Infection the Clinical Curative Effect and Security of the Peptic Ulcer

作　　者：关威 

机构地区：[1]抚远县人民医院消化内科,黑龙江抚远156500

出　　处：《糖尿病新世界》2016年第4期22-24,共3页Diabetes New World Magazine

摘　　要：目的探究黄连素辅助治疗2型糖尿病合并幽门螺旋杆菌型消化性溃疡的价值。方法选取2014年1月—2015年1月110例2型糖尿病合并幽门螺旋杆菌型消化性溃疡患者,通过随机分组的方法将其分为2组,实验组55例2型糖尿病合并幽门螺旋杆菌型消化性溃疡接受黄连素辅助治疗,对照组55例2型糖尿病合并幽门螺旋杆菌型消化性溃疡接受奥美拉唑、阿司匹林等药物治疗,对比2组2型糖尿病合并幽门螺旋杆菌型消化性溃疡患者经不同治疗方法治疗的效果,即溃疡愈合情况、Hp根除率以及不良反应等。结果实验组2型糖尿病合并幽门螺旋杆菌型消化性溃疡患者治疗的总有效率(100.00%)与对照组相比,差异无统计学意义(P>0.05);实验组患者Hp根治率为98.18%,对照组患者Hp根治率为94.55%,2组2型糖尿病合并幽门螺旋杆菌型消化性溃疡患者的Hp根治率相比,差异无统计学意义(P>0.05);实验组共计存在5.45%的患者出现不良反应,其主要不良反应为便秘、纳差,对照组共计存在20.00%的患者出现不良反应,其主要不良反应为口腔金属味、恶心、头晕,实验组2型糖尿病合并幽门螺旋杆菌型消化性溃疡患者不良反应发生率明显低于对照组(P<0.05)。结论给予2型糖尿病合并幽门螺旋杆菌型消化性溃疡黄连素辅助治疗,可以有效促进患者溃疡面的愈合,提高Hp根除率,同时可以降低患者药物治疗的不良反应,对提高2型糖尿病合并幽门螺旋杆菌型消化性溃疡患者治疗的效果、改善患者的生活质量十分有益。Objective To explore the adjuvant treatment of berberine in type 2 diabetic patients with Helicobacter pylori peptic ulcer value. Methods January 2014 - 2015 years 1 month of 110 cases with type 2 diabetes mellitus and type of H. pylori peptic ulcer patients, divided into two groups, the experimental group 55 cases of type 2 diabetes mellitus and type of H. pylori peptic ulcer received berberine adjuvant therapy, according to the group 55 cases received omeprazole, aspirin and other drugs in the treatment of type 2 diabetes mellitus and type of H. pylori peptic ulcer, contrast two groups of type 2 di- abetes mellitus complicated with Helieobacter pylori type digestion ulcer patients by different methods in the treatment of treatment effect, ulcer healing, HP eradication rate and adverse reaction etc. by random grouping method. Results The total effective experimental group of patients with type 2 diabetes mellitus with Helicobacter pylori type treatment of peptic ulcer （100%） compared with the control group, no significant difference （P〉O.05）; the patients in the experimental group Hp cure rate of 98.18% patients in the control group, the cure rate of Hp was 94.55%, 2 groups of type 2 diabetes mellitus compli- cated with Helicobacter pylori type of peptic ulcer patients compared to the cure rate of Hp, there is no obvious difference （P〉0.05）; the experimental group total 5.45% patients with adverse reactions, the main adverse reaction is constipation, anorexia, the control group total 20% patients with adverse reaction, the main adverse reactions were nausea, dizziness, metallic taste in the mouth, the experimental group of type 2 diabetes mellitus complicated with Helicobacter pylori peptic ulcer patients with adverse reaction rate was significantly lower than the control group（P〈0.05）. Conclusion Type 2 diabetes mellitus complicated with Helicobacter pylori type digestion ulcer berberine adjuvant therapy can promote the healing of ul- cer surface effectively, improve the eradication rate o

关 键 词：2型糖尿病 幽门螺旋杆菌 消化性溃疡 黄连素 辅助治疗 

分 类 号：R587[医药卫生—内分泌]