不同处方全肠外营养液的稳定性考察  

Stability Investigation of Total Parenteral Nutrition Solution of Different Prescriptions

作　　者：高声传[1] 李杨[1] 

机构地区：[1]沈阳军区总医院药剂科,沈阳110016

出　　处：《中国药房》2016年第8期1055-1057,共3页China Pharmacy

摘　　要：目的:考察临床常用全肠外营养液(TPN)中的不溶性微粒数及其配伍稳定性,为临床应用提供参考。方法:选择临床常用的6种TPN处方,按无菌操作规程配制后,在室温(25℃)下,分别考察其在0、1、4、8、24 h各时间点的外观、pH值、渗透压和不溶性微粒数。结果:配制后24 h内,各TPN的外观及pH值未见明显变化,渗透压均<900 m Osm/L。对其不溶性微粒数的考察结果显示,加入注射用脂溶性维生素后,TPN中的不溶性微粒数急剧增加,≥10μm和≥25μm的微粒数均超出药典规定范围;中/长链脂肪乳注射液、水溶性维生素、混合糖电解质和微量元素的加入,也使其不溶性微粒数增加。结论:中/长链脂肪乳注射液、脂溶性/水溶性维生素、维生素C、混合糖电解质和微量元素对TPN的不溶性微粒数均有一定的影响。OBJECTIVE：To investigate the number of insoluble particle in total parenteral nutrition（TPN）solutions and to provide reference for clinical application. METHODS：6 kinds of commonly used TPN prescriptions were selected. After prepared according to sterile operation procedure,TPN at 25 ℃ was investigated at 0,1,4,8 and 24 h in terms of appearance,p H value,osmotic pressure and the numbers of insoluble particles. RESULTS：The appearance and p H value of TPN had no significant change within 24 h after preparation,and osmotic pressures were all lower than 900 m Osm/L. Study results showed that the numbers of insoluble particles quickly increased,and ≥10 μm and ≥25 μm insoluble particles exceeded the limitation of Chinese Pharmacopoeia after Lipid-soluble vitamin for injection were injected into TPN. Medium/long chain fat emulsion injection,water-soluble vitamin,electrolytes and trace elements also increased the numbers of insoluble particles. CONCLUSIONS：Medium/long chain fat emulsion injection,lipid-soluble/water-soluble vitamin,vitamin C,electrolytes and trace elements have certain influence on the number of insoluble particle of TPN. To analyze the reason for the forming of insoluble particles has great meaning both for improving the TPN quality and reducing the harm of particles for patients.

关 键 词：全肠外营养液 不溶性微粒 配伍 稳定性 

分 类 号：R913[医药卫生—药学]