盐酸右美托咪定对中老年患者全麻拔管期心血管反应的影响  

Effects of Dexmedetomidine Hydrochloride on Cadiovascular Response of Middle Aged and Elderly Patients during Tracheal Extubation Period

作　　者：郑智文[1] 崔丹[2] 解志强[1] 陈杰[1] 李海燕[1] 

机构地区：[1]唐山市人民医院麻醉科,河北唐山063000 [2]唐山市人民医院ICU,河北唐山063000

出　　处：《中国药房》2016年第8期1123-1125,共3页China Pharmacy

摘　　要：目的:评价盐酸右美托咪定对中老年患者全麻拔管期心血管反应的影响。方法:选取行全身麻醉的中老年结直肠癌患者110例,按随机数字表法分为观察组和对照组,各55例。两组患者采用异氟醚进行吸入全身麻醉,根据手术时间对患者进行麻醉维持,观察组患者术毕静脉泵入盐酸右美托咪定0.5μg/kg,对照组患者术毕缓慢静脉泵入丙泊酚0.5μg/kg。比较两组患者拔管前10 min、拔管时和拔管后5、10 min的心率(HR)、平均动脉压(MAP),并记录两组患者血氧饱和度、呼吸恢复时间、睁眼时间和拔管时间。结果:拔管前10 min和拔管后10 min,两组患者HR、MAP水平比较,差异无统计学意义(P>0.05);拔管时和拔管后5 min,两组患者HR、MAP水平明显升高,但观察组明显低于对照组,差异有统计学意义(P<0.05)。两组患者血氧饱和度、呼吸恢复时间、拔管时间比较,差异无统计学意义(P>0.05),但观察组患者睁眼时间明显短于对照组,差异有统计学意义(P<0.05)。结论:盐酸右美托咪定能够明显降低中老年结直肠癌患者全麻拔管期心血管应激反应,缩短苏醒时间。OBJECTIVE：To evaluate effects of dexmedetomidine hydrochloride on cardiovascular response of middle aged and elderly patients during tracheal extubation period. METHODS：110 general anesthesia patients with colorectal cancer were collected and randomly divided into observation group and control group,with 55 cases in each group. All patients received general anesthesia with same dose. Observation group was given intravenous pump of dexmedetomidine hydrochloride 0.5 μg/kg after surgery,and control group was given intravenous pump of propofol 0.5 μg/kg. HR and MAP of 2 groups were compared 10 min before tracheal extubation,at the moment of tracheal extubation,5 and 10 min after tracheal extubation. The oxygen saturation of blood,the time of respiration recovery,opening eyes and extubation were recorded in 2 groups. RESULTS：There was no statistical significance in HR and MAP between 2 groups 10 min before extubation and 10 min after extubation（P〉0.05）. HR and MAP of observation group were significantly lower than those of control group at the moment of extubation and 5 min after extubation,the levels of HR and MAP were significantly increased in the 2 groups with statistical significance（P〈0.05）. There was no statistical significance in oxygen saturation of blood,the time of respiration recovery and extubation between 2 groups（P〉0.05）. The time of opening eyes in observation group was significantly shorter than in control group,with statistical significance（P〈0.05）. CONCLUSIONS：Dexmedetomidine hydrochloride could significantly decrease cardiovascular stress response and shorten recovery time of middle age and elderly patients with colorectal cancer during tracheal extubation period.

关 键 词：盐酸右美托咪定 心血管反应 结直肠癌 麻醉 拔管期 

分 类 号：R614.2[医药卫生—麻醉学] R969[医药卫生—外科学]