LXA_4、ALDH_1及PLGF在子宫内膜异位症患者中的表达及意义  

Serum LXA_4,ALDH_1 and PLGF levels in patients with endometriosis and their significance

作　　者：马睿[1] 刘洁[1] 成佳景[1] 

机构地区：[1]同济大学附属第十人民医院妇产科,上海200072

出　　处：《同济大学学报（医学版）》2016年第1期77-80,共4页Journal of Tongji University(Medical Science)

摘　　要：目的观察脂氧素A_4(LXA_4)、乙醛脱氢酶1(ALDH_1)和胎盘生长因子(placental growth factor,PLGF)在子宫内膜异位症(endometriosis,EMT)患者中的表达及意义。方法选取2012年1月至2014年1月经病理诊断为EMT的患者165例为异位内膜组,选择同期健康妇女30例为健康对照组。根据r-AFS将EMT分为Ⅰ期45例、Ⅱ期48例,Ⅲ期37例和Ⅳ期35例,根据痛经评分标准分为:0分53例,1分43例,2分37例和3分32例。观察异位内膜组和正常对照组的LXA_4、ALDH_1和PLGF水平变化及EMT患者的LXA_4、ALDH_1和PLGF水平与EMT分期和痛经评分的关系。结果异位内膜组的LXA_4水平明显低于正常对照组(P<0.01),ALDH_1和PLGF水平明显高于正常对照组(P<0.01)。随着EMT分期的升高和痛经评分的增加,LXA_4水平明显降低(P<0.01),而ALDH_1和PLGF水平明显升高(P<0.01)。结论 LXA_4、ALDH_1和PLGF的异常表达与EMT的发生发展具有重要联系,联合检测对EMT的早期诊断具有重要意义。Objective To detect the serum levels of lipoxin A4（ LXA4）,aldehyde dehydrogenase 1（ ALDH1） and placental growth factor（ PLGF） in patients with endometriosis（ EMT）.Methods One hundred and sixty five patients with EMT（ EMT group） and 30 health women（ control group） were enrolled in the study from January 2012 to January 2014. Forty five patients were classified as stageⅠ,48 as stageⅡ,37 as stage Ⅲ and 35 as stage Ⅳ,according to the American Association of Reproductive staging（ r-AFS）. Fifty three patients were classified as point 0,43 as point 1,37 as point 2and 32 as 3,according to dysmenorrhea score. Serum levels of LXA4,ALDH1 and PLGF were measured with ELISA method in endometriosis group and control group,and their relationship with EMT stage and dysmenorrhea score was analyzed. Results The serum levels of LXA4 in EMT group were significantly lower and the levels of ALDH1 and PLGF in EMT group were significantly higher than those in control group（ all P〈 0. 01）. The levels of LXA4 decreased and the levels of ALDH1 and PLGF increased as the EMT stage and dysmenorrhea score increasing（ P〈 0. 01）. Conclusion The results indicate that LXA4,ALDH1 and PLGF may be involved in the development and advancement in EMT,and the detection of these markers might be of value in early diagnosis of EMT.

关 键 词：脂氧素A4 乙醛脱氢酶1 胎盘生长因子 子宫内膜异位症 

分 类 号：R711.71[医药卫生—妇产科学]