原发性青光眼视放射损害的磁共振弥散张量成像研究  

Application of MR Diffusion Tensor Imaging in Primary Glaucoma Patients with Optic Radiation Damage

作　　者：张放[1] 文雯[2] 朱文卿[2] 沙炎[1] 叶昕裴[1] 王申江[1] 

机构地区：[1]复旦大学附属眼耳鼻喉科医院放射科 [2]复旦大学附属眼耳鼻喉科医院眼科

出　　处：《中国医学计算机成像杂志》2016年第1期17-21,共5页Chinese Computed Medical Imaging

基　　金：2012年上海市卫生局青年基金项目;项目编号:20124y097;国家自然科学基金青年基金(编号:81500752)~~

摘　　要：目的:探讨磁共振弥散张量成像(DTI)技术显示不同时期青光眼视放射神经变性的价值。方法:选择原发性青光眼早、晚期及正常对照组各15例行视觉通路DTI检查。分别测量左右两侧视放射的各向异性分数(FA)、平均弥散率(MD)、平行扩散率(λ//)和垂直扩散率(λ⊥),使用SPSS16.0统计学软件分析病变组与对照组各参数之间的差异。结果:与正常对照组比较,早期青光眼患者视放射FA值、λ//值轻度降低,MD值轻度增高,差异无统计学意义(P>0.05),λ⊥值显著升高(P=0.033);晚期青光眼患者视放射FA值、λ//值显著降低(P=0.000,P=0.028),MD值、λ⊥值显著升高(P=0.043,P=0.000)。晚期青光眼较早期青光眼视放射FA值显著降低(P=0.000),λ⊥值显著升高(P=0.001),MD值升高,λ//值降低,差异无统计学意义(P>0.05)。结论:DTI技术可以多参数显示不同时期青光眼视放射的神经变性,并能一定程度上反映病变严重程度,FA值和λ⊥值较MD值和λ//值更能敏感地反映视放射的损害。Purpose： To study the value of MR diffusion tensor imaging（DTI） in evaluating the neurodegenerative changes of optic radiations in primary glaucoma patients. Methods： Fifteen early glaucoma patients, 15 severe glaucoma patients, and 15 normal volunteers were enrolled.All subjects were undergone conventional MRI and DTI on a Siemens Verio 3T scanner. Fractional anisotropy（FA）,mean diffusivity（MD）,axial diffusivities（λ//） and radial diffusivities（λ ⊥） were measured in optic radiation area, and then the difference between patients group and control group was analyzed by using the statistical software of SPSS 16.0. Results： Compared with control group, the values of FA and λ// in early glaucoma weres lightly decreased, and that of MD weres lightly increased, which was with no statistical significant difference（P〈0.05）. While the value of λ ⊥ was significantly higher than that in control group（P=0.033）. In severe glaucoma, the values of FA and λ// were decreased obviously（P=0.000, P=0.028）, and the values of MD and λ ⊥ were increased significantly（P=0.043, P=0.000） than those in control group. Compared with early glaucoma, the value of FA in severe glaucoma was obviously decreased（P=0.000）, and that of λ ⊥ was significantlyincreased（P=0.001）. While the value of MD was slightly increased, that of λ// was slightly decreased, and no statistical significant difference could be found（P〈0.05）. Conclusions： DTI can detect the neurodegenerative abnormality of optic radiations in patients with different stages glaucoma and reflect the severity of damage in a certain extent. The values of FA and λ ⊥ are more sensitive than those of MD and λ// for the assessment of optic radiation damage.

关 键 词：原发性青光眼 扩散张量成像 视放射 

分 类 号：R445.2[医药卫生—影像医学与核医学]