同型半胱氨酸对高密度脂蛋白逆转运和抗氧化功能的影响  

Effect of homocysteine on reverse cholesterol transport and antioxidant function of HDL

作　　者：钟建开[1] 谭迎[1] 陈盈文[1] 王航鹰[1] 陈玉映[1] 吴焱贤[1] 

机构地区：[1]南方医科大学附属顺德第一人民医院心血管内科,佛山528300

出　　处：《中华老年心脑血管病杂志》2016年第3期233-236,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：广东省医学科学技术研究基金(B2014388;A2015219)

摘　　要：目的探讨同型半胱氨酸(Hcy)对HDL逆转运和抗炎抗氧化功能的影响。方法选择顺德第一人民医院住院患者120例,根据血Hcy水平,将患者分为正常对照组60例和高Hcy组60例,记录患者的人口学特点和检测血液生化指标,同时测定患者血卵磷脂胆固醇酰基转移酶(LCAT)和胆固醇酯转运蛋白(CETP)水平,患者HDL颗粒中的对氧磷酶1(PON1)、髓过氧化物酶(MPO)活性以及脂质过氧化物(LPO)含量。结果与正常对照组比较,高Hcy组患者血LCAT[(925.6±127.0)U/mg vs(1015.3±131.1)U/mg,P=0.000]、CETP[(26.3±4.1)μg/mg vs(34.6±5.0)μg/mg,P=0.000]和PON1[(213.4±71.4)U/ml vs(416.5±85.1)U/ml,P=0.000]活性显著降低,MPO[(4.8±1.9)U/L vs(3.3±1.5)U/L,P=0.000]活性和LPO[(0.93±0.08)U/L vs(0.83±0.09)U/L,P=0.000]含量显著升高。结论高Hcy通过降低血LCAT、CETP浓度,降低HDL胆固醇逆转运功能,并通过降低HDL颗粒中PON1活性,升高HDL颗粒中MPO活性,导致HDL颗粒中LPO含量升高,从而降低HDL的抗炎抗氧化功能。Objective To study the effect of homocysteine （Hcy） on reverse cholesterol transport and antioxidation function of HDL. Methods One hundred and twenty patients admitted to our hospital were divided into control group （n=60） and high Hcy group （n=60）. Their demographic and biochemical data were recorded. Their serum levels of LCAT and CETP, and activity of PON1,MPO and LPO in HDL were measured. Results The serum levels of LCAT [（925.6± 127.0）U/mg vs （1015.3±131.1）U/mg,P=0. 000] and CETP [（26.3±4. 1）μg/mg vs （34.6±5.0）μg/mg,P=0. 000],and the activity of PON1 [（213.4±71.4）U/ml vs （416.5±85.1）U/ml, P=0. 000-] were significantly lower whereas the activity of MPO [（4.8±1.9）U/L vs （3.3±1.5） U/L,P=0. 000] and the serum level of LPO [（0. 9320. 08）U/L vs （0. 8320. 09）U/L,P= 0. 000] were significantly higher in high Hcy group than in control group. Conclusion High Hcy level reduces reverse cholesterol transport by decreasing the serum levels of LCAT and CETP, and increases the activity of MPO and decreases the antioxidant function of HDL by increasing the activity of MPO and reducing the activity of PON1.

关 键 词：高半胱氨酸 脂蛋白类 HDL 磷脂酰胆碱-甾醇O-酰基转移酶 胆固醇酯转运蛋白质类 过氧化物酶 

分 类 号：R54[医药卫生—心血管疾病] R446.11[医药卫生—内科学]