Interleukin 8 Gene Polymorphisms Are Not Associated with Tuberculosis Susceptibility in the Chinese Population  

作　　者：MA Yan LIU Yu Hong ZHANG Zhi Guo WANG Li YANG Xiao Wei LI Chuan You CHE Nan Ying 

机构地区：[1]Center office, Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing 101149, China [2]Beijing Chest Hospital, Capital Medical University, Beijing 101149, China [3]Clinical Center on Tuberculosis, China CDC, Beijing 101149, China [4]Beijing Changping Center for Tuberculosis Control and Prevention, Beijing 102200, China [5]Department of Bacteriology and Immunology, Beijing Tuberculosis & Thoracic Tumor Research Institute [6] Beijing Chest Hospital, Capital Medical University, Beijing 101149, China [6]Department of Pathology, Beijing Tuberculosis & Thoracic Tumor Research Institute Beijing Chest Hospital, Capital Medical University, Beijing 101149, China

出　　处：《Biomedical and Environmental Sciences》2016年第2期158-161,共4页生物医学与环境科学（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(Grant Number:81572077);Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special(Grant Number:XMLS201506);Beijing Health System Training Program for High Level Technique Talents(Grant Number:2014-3-082);the Capital Health Research and Development of Special(Grant Number:2014-4-2161)

摘　　要：Interleukin 8 （IL8） is an important chemokine that elicits host immune response against tuberculosis （TB）. However, whether there is an association between IL8 gene polymorphism and TB susceptibility in the Chinese population is unknown. IL8 gene was amplified and sequenced to search for nucleotide polymorphisms among the Chinese population. Four single nucleotide polymorphisms （SNPs） were identified, selected, and analyzed in a cohort of 438 patients with TB and 536 healthy controls. Allelic, genotypic, and haplotypic analysis demonstrated that the distribution of the four IL8 SNPs between patients with TB and healthy controls was not significantly different （P〉0.05）. The four IL8 SNPs detected in this study were not associated with TB susceptibility in the Chinese population. Secretion of IL8 by peripheral blood cells was greatly stimulated upon exposure to Mycobacterium tuberculosis whole cell extract, but such enhanced secretion was not associated with the IL8 rs4073 alleles.Interleukin 8 （IL8） is an important chemokine that elicits host immune response against tuberculosis （TB）. However, whether there is an association between IL8 gene polymorphism and TB susceptibility in the Chinese population is unknown. IL8 gene was amplified and sequenced to search for nucleotide polymorphisms among the Chinese population. Four single nucleotide polymorphisms （SNPs） were identified, selected, and analyzed in a cohort of 438 patients with TB and 536 healthy controls. Allelic, genotypic, and haplotypic analysis demonstrated that the distribution of the four IL8 SNPs between patients with TB and healthy controls was not significantly different （P〉0.05）. The four IL8 SNPs detected in this study were not associated with TB susceptibility in the Chinese population. Secretion of IL8 by peripheral blood cells was greatly stimulated upon exposure to Mycobacterium tuberculosis whole cell extract, but such enhanced secretion was not associated with the IL8 rs4073 alleles.

关 键 词：TB FIGURE 

分 类 号：R52[医药卫生—内科学]