电刺激犬心室神经节丛对自主神经介导房颤的影响  

Effect of electrical stimulation of aortic root ventricular ganglionated plexi on autonomic nervous system-mediated atrial fibrillation

作　　者：范博渊[1] 何宜轩 王彬[1] 艾永飞[1] 马文帅[1] 赵楠楠[1] 王洪涛[1] 

机构地区：[1]第四军医大学唐都医院心脏内科,陕西西安710038 [2]第四军医大学学员旅二营五连,陕西西安710032

出　　处：《心脏杂志》2016年第2期149-152,共4页Chinese Heart Journal

基　　金：陕西省自然科学基金项目资助(2015JM8461)

摘　　要：目的本研究探讨低频电刺激心室主动脉根部神经节丛(ganglionated plexi,GP)对肺静脉源性房颤(AF)诱发率的影响。方法 20只犬分别测量基础状态下,高频和低频电刺激主动脉根部GP时的心房有效不应期和肺静脉有效不应期。分别在基础状态下,高频和低频电刺激主动脉根部GP时,自肺静脉远端以程序刺激诱发AF和AF诱发率的变化。结果高频电刺激主动脉根部GP明显缩短心房的肺静脉的有效不应期,增加AF的诱发率。而低频电刺激使心房及肺静脉有效不应期呈延长趋势,并降低AF诱发率。结论低频电刺激主动脉根部GP降低自主神经介导的AF诱发率。AIM To investigate the effect of electrical stimulation of aortic root ventricular ganglionated plexi （GP） on autonomic nervous system-mediated atrial fibrillation （AF） inducibility. METHODS Effective refractory periods （ERP） of the atria and the pulmonary vein （PV） were measured at baseline, high-level （HL-ES） and low-level （LL-ES） electrical stimulation of aortic root ventricular GP. AF was induced at distal PV by programmed stimulation to measure AF inducibility at baseline, HL-ES or LL-ES. RESULTS HL-ES of aortic root GP significantly shortened ERP of the atria and ERP of the PVs and increased the AF-inducing rate arising from PVs. However, LL-ES of this GP prevented the shortening of ERP and decreased AF inducing rate. CONCLUSION LL-ES of aortic root ventricular GP decreases AF inducibility arising from PVs mediated by the autonomic nervous system.

关 键 词：心室主动脉根部神经节丛 自主神经系统 肺静脉 房颤 

分 类 号：R541.75[医药卫生—心血管疾病]