阿托伐他汀对犬心房及肺静脉电活动的影响  

Effects of atorvastatin on atrial and pulmonary vein electrical activity

作　　者：石铭宇[1] 滕世超[1] 姜丽[1] 朱静[1] 尹峰[1] 谷宏越[1] 

机构地区：[1]哈尔滨医科大学附属第一医院心内科,黑龙江哈尔滨150001

出　　处：《心脏杂志》2016年第2期157-159,共3页Chinese Heart Journal

基　　金：黑龙江省教育厅科学技术研究项目资助(12511306)

摘　　要：目的观察阿托伐他汀对犬心房及肺静脉电活动的影响。方法将实验动物犬随机分为对照组(n=7)和试药组(n=7),其中试药组于术前4周每天服用阿托伐他汀(2 mg/kg)直至术前结束。之后分别测各组犬心房及肺静脉不应期,并进行房颤的诱发。结果试药组犬的心房各部位不应期均较对照组延长,频率适应性较对照组提高。在房颤的诱发中,试药组房颤的诱发率较对照组低。结论阿托伐他汀可有效改善犬的心房电活动,从而对房颤的发生及复发起到抑制作用。AIM To observe the effects of atorvastatin on atrial and pulmonary vein electrical activity. METHODS Fourteen dogs were randomly divided into the control group （n = 7 ） and the atorvastatin group （n =7）, and atorvastatin was administered orally （2 mg/kg/day） 4 weeks before operation. The atrial effective refractory period （AERP） and pulmonary vein effective refractory period （AERP） were determined. RESULTS Atorvastatin group had a longer AERP and a longer AERP rate adapting feature. In induced atrial fibrillation, the atorvastin group had a lower rate than the control group. CONCLUSION Atorvastatin effectively improves the atrial electrical activity and reduces the occurrence and recurrence of atrial fibrillation.

关 键 词：心房颤动 阿托伐他汀 有效不应期 

分 类 号：R541.7[医药卫生—心血管疾病]