Study on the Synthesis and Antitumor Activity of New Indolocarbazole Compounds  

作　　者：ZHAO Ling-Ling ZHAI Fu-Min XIE Ming-Chao QI Ganga 

机构地区：[1]Department of Chemistry and Chemical Engineering,Yancheng Institute of Technology,Yancheng 224051,China [2]Jiangsu Wanquan Pharmaceutical Biotechnology Company,Taizhou 225300,China [3]Binhai County Safety Supervision Bureau,Yancheng 224500,China

出　　处：《Chinese Journal of Structural Chemistry》2016年第2期205-211,共7页结构化学（英文）

基　　金：supported by the science and technology support project of Jiangsu Province(No.BY2015057-03)

摘　　要：A series of new antitumor compounds having indolecarbazole structures were designed and synthesized. The methoxy substituted indolecarbazole parent nucleus, which was firstly synthesized, is condensed with bromine substituted amino acid methyl ester to produce the target compounds. The target compounds were performed with methylthiazolyldiphenyl-tetrazolium bromide（MTT） in vitro cytotoxin activity test and the results showed that compounds CZ-1, CZ-3 and CZ-6 have higher activity against human colon cancer（HT-29） and（HCT-8）, hepatocellular carcinoma（Bel-7402）, NSCLC（A549） and breast cancer（MCF-7） cells as compared to the positive control JDC-108.A series of new antitumor compounds having indolecarbazole structures were designed and synthesized. The methoxy substituted indolecarbazole parent nucleus, which was firstly synthesized, is condensed with bromine substituted amino acid methyl ester to produce the target compounds. The target compounds were performed with methylthiazolyldiphenyl-tetrazolium bromide（MTT） in vitro cytotoxin activity test and the results showed that compounds CZ-1, CZ-3 and CZ-6 have higher activity against human colon cancer（HT-29） and（HCT-8）, hepatocellular carcinoma（Bel-7402）, NSCLC（A549） and breast cancer（MCF-7） cells as compared to the positive control JDC-108.

关 键 词：indolecarbazole antitumor activity cytotoxin activity 

分 类 号：O626[理学—有机化学] TQ460.1[理学—化学]