四妙勇安汤加味治疗中风后癫痫35例临床观察  

Clinical efficacy of Jiawei Simiao Yongan decoction in treatment of post-stroke epilepsy: a report of 35 cases

作　　者：蒋士生[1] 韩育明[1] 夏爱民[1] 王红梅[1] 何飞舟[1] 贺双腾[1,2,3] 

机构地区：[1]湖南省中医药研究院,湖南长沙410006 [2]中南大学湘雅医院中西医结合研究所,湖南长沙410008 [3]Stroke Research Laboratory,Kansas City VA Medical Center

出　　处：《湖南中医杂志》2016年第2期1-4,共4页Hunan Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(编号:39670870;81373601);湖南省自然科学基金资助项目(编号:2000-00JJY2035;2012WK3008);湖南省卫生厅资助项目(编号:2000-00104)

摘　　要：目的:观察四妙勇安汤加味治疗中风后癫痫的临床疗效。方法:选取70例中风后癫痫患者随机分为对照组和治疗组各35例,对照组以西医常规治疗合西药左乙拉西坦口服治疗,治疗组在西医常规治疗的基础上或停用西医常规治疗的情况下予四妙勇安汤加味治疗。观察比较两组的癫痫控制率、起效时间、癫痫复发率、脑电图改善、神经功能康复评分(NIHSS)、不良反应6项指标。结果:完成治疗的例数治疗组为34例,对照组为26例;癫痫控制例数治疗组为31例,对照组为24例;癫痫复发例数治疗组为1例,对照组为7例;治疗后治疗组的NIHSS评分、脑电图异常例数分别为(5.7±1.4)分、20例,对照组分别为(9.3±2.5)分、22例;对照组出现皮疹4例、乏力4例、头晕头痛2例,治疗组出现腹泻3例。以上6项指标两组间比较,差异均有统计学意义(均P<0.05)。但平均起效时间两组相当,差异无统计学意义(P>0.05)。结论:四妙勇安汤加味治疗中风后癫痫价廉效佳,且毒副作用小,值得临床推广应用。Objective： To observe the clinical efficacy of Jiawei Simiao Yongan decoction in the treatment of post stroke epilepsy. Methods： Seventy patients with post- stroke epilepsy were randomly and equally divided into control group and treatment group. The control group received conventional Western medicine treatment combined with oral levetiracetam,while the treatment group received Jiawei Simiao Yongan decoction alone or in combination with the conventional Western medicine treatment. The two groups were compared in terms of epilepsy control rate,onset time,epilepsy recurrence rate,electroencephalographic improvement,National Institutes of Health Stroke Scale（ NIHSS） score,and adverse events. Results： Treatment was completed in 34 cases in the treatment group and 26 cases in the control group; epilepsy was controlled in 31 cases in the treatment group and 24 cases in the control group; epilepsy recurred in 1 case in the treatment group and 7 cases in the control group. After treatment,the treatment group had an NIHSS score of 5. 7 ± 1. 4 and 20 cases of electroencephalographic abnormalities,versus 9. 3 ±2. 5 and 22 cases in the control group. In the control group,4 cases experienced rash,4 cases weakness,2 cases dizziness and headache; in the treatment group,3 cases experienced diarrhea. There were significant differences in the above six indices between the two groups（ all P〈 0. 05）,but no significant difference was found in mean onset time（ P〉0. 05）. Conclusion： Jiawei Simiao Yongan decoction is inexpensive and effective in the treatment of post-stroke epilepsy and has little toxic or side effect. It holds promise for clinical application.

关 键 词：中风后癫痫 中医药疗法 四妙勇安汤加味 

分 类 号：R277.721[医药卫生—中医学]