Recent progress in the discovery of inhibitors targeting coronavirus proteases  

作　　者：Haofeng Wang Song Xue Haitao Yang Cheng Chen 

机构地区：[1]School of Life Sciences, Tianjin University

出　　处：《Virologica Sinica》2016年第1期24-30,共7页中国病毒学（英文版）

基　　金：supported by the Tianjin University Undergraduate Research Foundation;Tianjin University-Hainan University Collaborative Foundation;National Natural Science Foundation of China (No.31300150);Tianjin Marine Science and Technology Program (No.KJXH2014-16)

摘　　要：Coronaviruses(CoVs) can cause highly prevalent diseases in humans and animals. The fatal outbreak of severe acute respiratory syndrome(SARS) and Middle East respiratory syndrome(MERS) highlights the threat posed by this unique virus subfamily. However, no specific drugs have been approved to treat CoV-associated diseases to date. The CoV proteases, which play pivotal roles in viral gene expression and replication through a highly complex cascade involving the proteolytic processing of replicase polyproteins, are attractive targets for drug design. This review summarizes the recent advances in biological and structural studies, together with the development of inhibitors targeting CoV proteases, particularly main proteases(M^(pro)s), which could help develop effective treatments to prevent CoV infection.Coronaviruses（CoVs） can cause highly prevalent diseases in humans and animals. The fatal outbreak of severe acute respiratory syndrome（SARS） and Middle East respiratory syndrome（MERS） highlights the threat posed by this unique virus subfamily. However, no specific drugs have been approved to treat CoV-associated diseases to date. The CoV proteases, which play pivotal roles in viral gene expression and replication through a highly complex cascade involving the proteolytic processing of replicase polyproteins, are attractive targets for drug design. This review summarizes the recent advances in biological and structural studies, together with the development of inhibitors targeting CoV proteases, particularly main proteases（M^（pro）s）, which could help develop effective treatments to prevent CoV infection.

关 键 词：coronaviruses main protease protease inhibitors 

分 类 号：R91[医药卫生—药学]