中药抗脂肪肝活性发现与药效评价的动物模型应用概况与研制思路  

Overview and Application in Establishing Animal Models against Fatty Liver Disease for Active Discovery and Efficacy Evaluation of Chinese Medicine

作　　者：孙晓倩[1,2] 孙蓉[1] 

机构地区：[1]山东省中医药研究院,山东济南250014 [2]山东中医药大学,山东济南250355

出　　处：《中国药物警戒》2016年第2期90-93,共4页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金面上项目(81374059);山东省自主创新和成果转化项目(2014ZZCX02104)

摘　　要：目的以脂肪肝病因病机为基础,紧密联系中医临床实际,确定并提出适宜于中药活性发现和药效评价的、稳定和可靠的脂肪肝动物模型。方法对国内外近10年发表的脂肪肝动物模型研究、评价的文献进行整理、归纳和分析。结果目前脂肪肝模型较多,其造模方法、机制、应用各不相同,在中药药效评价和病理机制研究中尚存在模型灵敏性、可靠性、稳定性方面的问题。结论随着现代医学发展和实验技术提高,尤其是脂肪肝早期代谢靶标的发现,精准制备各种诱因的脂肪肝模型成为可能。中医对脂肪肝的认知与现代医学既有相合之处,也有自身脏腑辨证特色,加强中医病因病机及病证演变规律研究,为构建适宜于中药抗脂肪肝活性发现和药效评价的、稳定和可靠的,符合中医病证演变规律的脂肪肝模型奠定基础,为抗脂肪肝创新中药发现和评价提供方法学保证和有效的药物筛选与研发工具。Objective To establish the animal model of fatty liver with the basis of etiology and pathogenesis of fatty liver disease and the clinical practice of TCM, which is stable and reliable and is suitable for the activity and efficacy evaluation of TCM. Methods References in the last decades at home and abroad about the animal model of fatty liver were collected, summarized and analyzed. Results There are many models of fatty liver at present, though the mechanisms and applications of models are different and there are many problems in the study of the efficacy evaluation and pathological mechanism of TCM, such as sensitivity, reliability and stability of the model. Conclusion With the development of modern medicine and the improvement of experimental technology, especially the early metabolic target of fatty liver discovered, the fatty liver model caused by varieties of inducements is possible. Cognition of fatty liver model with TCM and modern medicine is consistency, but also which is own characteristics of viscera. The fatty liver model is established by the study of etiology and pathogenesis and disease-syndrome development regularity, which is suitable for evaluating the activity and efficacy of TCM anti-fatty liver and accords with the disease-syndrome development regularity of TCM, for providing methodology and technology of screening and discovering antifatty liver drugs.

关 键 词：脂肪肝 动物模型 药效评价 

分 类 号：R965[医药卫生—药理学] R285.5[医药卫生—药学]