星点设计-效应面法优化葛根素PGFE胶束聚合物制备工艺  

Optimized preparation of puerarin PGFE micelle-polymer by a central composite design-response surface method

作　　者：吴卫[1] 李素珍[2] 陈俐秀 朱碧婧 刘为萍[2] 

机构地区：[1]桂林医学院药学院,桂林541004 [2]桂林医学院附属医院临床医学实验教学中心,桂林541001

出　　处：《中华中医药杂志》2016年第3期968-970,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81560653);广西自然科学基金项目(No.2014GXNSFBA118190)~~

摘　　要：目的:用聚甘油脂肪酸脂(PGFE)作为一种新型药物载体材料,以葛根素为模型药物,制备葛根素PGFE胶束聚合物。方法:采用紫外分光光度法测定葛根素含量,以药物包封率作为评价指标,通过星点设计-效应面优化法对葛根素PGFE胶束聚合物的制备工艺及处方进行优化。结果:PGFE胶束聚合物可以有效地包裹或吸附葛根素,稳定性良好,包封率可达80%以上。结论:以PGFE作为药物载体材料,能自发形成胶束聚合物微粒,可改善难溶性药物的溶解度。Objective： Polyglycerol fatty acid ester（PGFE） was used as a novel drug carrier material, puerarin was used as a model drug, and the puerarin PGFE micelle-polymers were prepared. Methods： The content of puerarin was determined by UV spectrophotometry, with drug entrapment efficiency as evaluation index, the prescription and preparation technology of puerarin PGFE micelle-polymers were optimized by central composite design and response surface optimization method. Results： Puerarin could be effectively wrapped or absorption by PGFE micelle-polymers with good stability, the encapsulation efficiency could reach 80%. Conclusion： With PGFE as a drug carrier material, it can form micelle-polymer particles spontaneously, which can improve the solubility of poorly water-soluble drugs.

关 键 词：聚甘油脂肪酸脂 星点设计 效应面法 葛根素 

分 类 号：R283.6[医药卫生—中药学]