葫芦岛地区育龄期女性甲状腺功能指标的调查研究  

Thyroid function of women of reproductive age in Huludao city

作　　者：刘洋[1] 梅迪[2] 申爽[1] 李野[1] 

机构地区：[1]葫芦岛市中心医院检验科,辽宁葫芦岛125000 [2]葫芦岛市中心医院普外科,辽宁葫芦岛125000

出　　处：《中国微生态学杂志》2016年第3期340-342,共3页Chinese Journal of Microecology

摘　　要：目的探讨葫芦岛地区育龄期女性甲状腺功能水平与孕前促甲状腺激素(TSH)、抗甲状腺过氧化物酶抗体(TPO-Ab)筛查对优生优育的意义。方法选择葫芦岛市1 540例育龄女性,采用罗氏电化学发光E602检测血清TSH、游离甲状腺素(FT4)、游离三碘甲腺原氨酸(FT3)和TPO-Ab。结果 1 540例育龄妇女中,TSH异常135例,总异常率为8.7%,不同年龄组间TSH的异常率差异有统计学意义(χ2=33.56,P<0.05)。TPO-Ab总阳性率为8.2%,TSH正常与异常组间的比较差异有统计学意义(χ2=34.84,P<0.05)。进一步分层分析,TSH异常者中,甲亢与甲减组TPO-Ab阳性率的比较组间差异无统计学意义(χ2=0.043,P>0.05)。结论葫芦岛地区育龄期女性甲状腺功能异常率较高,应对孕产妇常规进行甲状腺功能检测。Objective To learn the thyroid function of women at reproductive age in Huludao city.Methods 1,540 women of reproductive age were enrolled.The markers of thyroid function,such as thyroid stimulating hormone（TSH）,free triiofothyronine（FT3）,free thyroxine（FT4）,and anti thyroid peroxidase antibody（TPO-Ab） were determined with the electrochemiluminescence immunoassay（Roche MYE602）.Results Among the 1,540 cases,the total abnormality rate of TSH was 8.7%,which was significantly different among different age groups（P〈0.05）.The total positive rate of TPO-Ab was8.2%,which was significantly different between normal and abnormal TSH groups（P〈0.05）.Further stratification analysis indicated that there is no significant difference in TOP-Ab between the hyperthyroidism and hypothyroidism groups（P〉0.05）.Conclusion The abnormality rate of thyroid function is relatively high in Huludao region.It is necessary to routinely monitor thyroid function among women of reproductive age.

关 键 词：育龄妇女 促甲状腺激素 甲状腺功能亢进 甲状腺功能减退 甲状腺过氧化物酶抗体 

分 类 号：R581[医药卫生—内分泌]