亚磷酰胺配体在铱催化不对称氢化反应中的应用  

Applications of Phosphoramidite Ligands in Ir-Catalyzed Asymmetric Hydrogenation Reactions

作　　者：袁乾家[1] 张万斌[1] 

机构地区：[1]上海交通大学化学化工学院,上海200240

出　　处：《有机化学》2016年第2期274-282,共9页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21232004);上海市优秀学科带头人(No.14XD1402300)资助项目~~

摘　　要：亚磷酰胺化合物,作为一类"优势手性配体",经过近二十年的发展已经被证明可适用于不对称催化氢化、不对称催化烯丙基取代和不对称催化Diels-Alder反应等多种类型的不对称催化反应.以最具工业化前景的不对称催化氢化反应为切入点,综述了亚磷酰胺配体在铱催化烯酰胺及其衍生物、非官能团烯胺、亚胺及芳香杂环化合物的不对称氢化反应中的研究进展.Phosphoramidites, as a class of privileged chiral ligands, are suitable for different types of reactions, such as catalytic asymmetric hydrogenation, catalytic asymmetric allylic substitution, catalytic asymmetric Diels-Alder reaction and so on. Catalytic asymmetric hydrogenation reactions are some of the most important reactions in industry. In this review recent advances and applications of phosphoramidite ligands in Ir-catalyzed asymmetric hydrogenation of enamides and their derivatives, unfunctionalized enamines, imines and heteroaromatic compounds are discussed.

关 键 词：亚磷酰胺配体 铱 不对称催化氢化 

分 类 号：O621.251[理学—有机化学]