3-C位单取代环维黄杨星D衍生物的合成及其抗耐缺氧活性研究  

Synthesis and Anti-anoxia Activities of 3-C Mono-substituted Cyclovirobuxine D Derivatives

作　　者：向涛[1] 杨鸿均[1] 陈程[1] 冯豫川[1] 

机构地区：[1]西南民族大学化学与环境保护工程学院,成都610041

出　　处：《有机化学》2016年第2期432-436,共5页Chinese Journal of Organic Chemistry

基　　金：西南民族大学研究生创新型科研(No.CX2014SZ60);西南民族大学中央高校基本科研业务费专项资金(No.2014NZYQN21)资助项目~~

摘　　要：以植物活性单体环维黄杨星D为先导物,设计合成了7个新型的含氮杂环的环维黄杨星D衍生物,其结构经1H NMR,HRMS和IR鉴定.初步的抗耐缺氧活性研究结果表明,合成的新化合物具有一定的抗耐缺氧活性,其中含哌嗪基取代的衍生物活性较好.Seven novel cyclovirobuxine D derivatives were designed and synthesized by using cyclovirobuxine D as a starting material. All compounds synthesized were confirmed by 1H NMR, HRMS and IR. Preliminary results of anti-anoxia activity indicated that compounds displayed different degrees of activity, among them the compounds with piperazinyl exhibited higher anti-anoxia activity than others.

关 键 词：环维黄杨星D 合成 抗耐缺氧活性 

分 类 号：O626[理学—有机化学] TQ460.1[理学—化学]