苦参素对乙型肝炎患者免疫及纤维化状态的治疗研究  

Study on kushenin for treatment of immune and fibrosis status of patients with hepatitis B

作　　者：高海丽[1] 杨道坤[1] 梁海军[1] 王新伟[1] 王燕平[1] 陈宝鑫[1] 乔汉臣[1] 

机构地区：[1]新乡医学院第一附属医院感染三科,河南新乡453100

出　　处：《中华医院感染学杂志》2016年第5期985-987,共3页Chinese Journal of Nosocomiology

基　　金：河南省科技厅基金资助项目(201402KF)

摘　　要：目的研究及观察苦参素对乙型肝炎患者免疫及纤维化状态的影响程度,为乙型肝炎治疗方法的选取提供参考依据。方法选取2014年1月-2015年2月在医院进行治疗的70例乙型肝炎患者为研究对象,将其随机分为常规乙型肝炎治疗(对照组)35例和常规治疗加苦参素(观察组)35例,将两组患者治疗前和治疗后3个月及6个月的细胞免疫、红细胞免疫及血清纤维化指标进行比较,检验数据采用SPSS15.0软件进行统计分析。结果治疗前两组患者的细胞免疫、红细胞免疫及血清纤维化指标差异均无统计学意义,而治疗后3个月及6个月观察组的CD3+、CD4+及免疫黏附促进因子(FEER)、促肿瘤红细胞花环率(ETER)水平均高于对照组,而CD8+、免疫黏附抑制因子(FEIR)及血清Ⅲ型前胶原肽(PⅢP)、层粘连蛋白(LN)、透明质酸(HA)水平则均低于对照组,差异均有统计学意义(P<0.05)。结论苦参素可有效改善乙型肝炎患者的免疫状态,且对于患者的纤维化状态也有积极的控制效果。OBJECTIVE To study and observe the influence degree of kushenin on the immune and fibrosis status of patients with hepatitis B,in order to provide reference for the selection of treatment methods.METHODS Totally70 patients with hepatitis B in our hospital from Jan.2014 to Feb.2015 were selected as the study subjects,and they were randomly divided into the control group（conventional treatment of hepatitis B,n=35）and the observation group（conventional treatment and kushenin,n=35）.The cellular immune,erythrocyte immune and serum fibrosis indexes of two groups before the treatment and at third and sixth month after the treatment were compared.RESULTS The cellular immune,erythrocyte immune and serum fibrosis indexes of two groups before the treatment had no significant differences,while CD3^＋,CD4^＋ and regulator factor enhance rate（FEER）,enhanced tumor erythrocyte rosette（ETER）of the observation group at third and sixth month after the treatment were（56.32±6.14）,（46.87±4.85）,（52.78±5.31）,（43.48±4.26）and（60.72±6.41）,（48.56±5.07）,（55.97±5.68）,（45.86±4.66）,all higher than those of the control group,and CD8＋,immune adherence inhibitor factor（FEIR）and serum procollagen-Ⅲ-peptide（PⅢP）,laminin（LN）,hyaluronic acid（HA）were all lower than those of the control group,the differences were significant（all P〈0.05）.CONCLUSION Kushenin can effectively improve the immune state of patients with hepatitis B,and it also has active control effect on the fibrosis status of patients.

关 键 词：乙型肝炎 免疫状态 纤维化状态 

分 类 号：R512.62[医药卫生—内科学]