老年胃癌患者胃切除术后感染病原菌分析与对JAK/STAT蛋白的影响研究  

Distribution of pathogens causing postoperative infections in elderly gastric cancer patients undergoing gastrectomy and impact on serum JAK/STAT

作　　者：金恩鸿[1] 于强宗 刘广宇[2] 朴红心[3] 王雅岩[4] 

机构地区：[1]延边大学附属医院胃肠外科,吉林延吉133000 [2]延边大学临床医学院,吉林延吉133000 [3]延边大学附属医院感染科,吉林延吉133000 [4]延边大学附属医院呼吸内科,吉林延吉133000

出　　处：《中华医院感染学杂志》2016年第5期1002-1004,共3页Chinese Journal of Nosocomiology

基　　金：吉林省科技厅基金资助项目(吉科合2013-037)

摘　　要：目的分析老年胃癌患者胃切除术后感染病原菌,并探讨其感染对JAK/STAT蛋白的影响,为临床治疗提供参考。方法对医院2010年3月-2014年3月诊治的220例老年胃癌胃切除术后感染患者进行分析,作为感染组,以胃癌胃切除术后未感染老年患者为未感染组,以同期100名健康体检者为对照组;采用全自动微生物鉴定仪对病原菌进行鉴定分析,ELISA法检测3组受试人员血清中白细胞介素、JAK1/2及STAT3的水平变化。结果感染患者分离出病原菌中革兰阳性菌125株占56.8%,其中表皮葡萄球菌26株占11.8%,革兰阴性菌95株占43.2%,其中大肠埃希菌25株占11.4%;感染患者血清中JAK1/2、STAT3及IL-1/6/9水平明显高于未感染组及对照组。结论老年胃癌患者胃切除术后易受到病原菌感染,且发生明显炎症反应,可其能与JAK/STAT蛋白通路相关。OBJECTIVE To investigate the distribution of pathogens causing postoperative infections in the elderly gastric cancer patients undergoing gastrectomy and observe the influence of the infections on serum JAK/STAT so as to provide guidance for clinical treatment.METHODS From Mar 2010 to Mar 2014,a total of 220 elderly gastric cancer patients who underwent the gastrectomy and were complicated with postoperative infections were enrolled in the study and assigned as the infection group,the elderly gastric cancer patients without postoperative infections were set as the non-infection group,meanwhile,100 healthy people who received the physical examination were chosen as the control group.The pathogens were identified by using automatic microorganism identification system,and the levels of serum interleukins,JAK1/2and STAT3 of the three groups of participants were detected with the use of ELISA.RESULTS Of the pathogens isolated from the patients with infections,125（56.8%）strains of gram-positive bacteria,of which 26（11.8%）were the Staphylococcus epidermidis,and 95（43.2%）strains of gram-negative bacteria,of which 25（11.4%）were the Escherichia coli.The levels of serum JAK1/2,STAT3,and IL-1/6/9were significantly higher in the infection group than in the non-infection group and the control group.CONCLUSIONThe elderly gastric cancer patients are at high risk of the infections after the gastrectomy and have remarkable inflammatory reactions,which may be related to the JAK/STAT pathway.

关 键 词：胃癌 老年患者 病原菌 JAK/STAT蛋白 

分 类 号：R656.61[医药卫生—外科学]