人乳头状瘤病毒感染与宫颈癌发病关系的临床分析  

Clinical analysis of relationship between human papillomavirus infections and cervical cancer

作　　者：孙彦珍[1] 袁征[1] 李珍[1] 张子杰[1] 王晶璇 

机构地区：[1]南阳市中心医院病理科,河南南阳473000

出　　处：《中华医院感染学杂志》2016年第5期1132-1134,共3页Chinese Journal of Nosocomiology

基　　金：河南省医学科研基金资助项目(2010SFXM224)

摘　　要：目的探讨人乳头状瘤病毒(HPV)感染与宫颈癌发病关系,为临床预防宫颈癌提供参考依据。方法选取医院2012年1月-2014年12月50例行宫颈癌活检或宫颈癌根治术患者宫颈癌组织标本作为研究组,50例子宫肌瘤切除术患者的宫颈组织标本作为对照组,采取免疫组织化学染色法测定两标本中HPV感染情况,并分析HPV感染与宫颈癌临床特征的相互关系,研究数据均采取SPSS19.0统计软件进行处理。结果研究组中HPV感染率46.0%,明显高于对照组的4.0%,两组数据比较差异有统计学意义(P<0.05);通过对HPV感染与宫颈癌临床特征的相互关系分析,未闭经患者中HPV感染率66.7%,明显高于闭经患者的15.0%;临床Ⅱ期患者中HPV感染率87.5%,明显高于Ⅰ期患者的26.5%;淋巴结转移患者中HPV感染率83.3%,明显高于淋巴结无转移患者的25.0%;病理学组织分级3级患者中HPV感染率80.0%,明显高于病理学组织分级1、2级的30.0%、40.0%,以上差异均有统计学意义(P<0.05)。结论 HPV在宫颈癌中具有较高的感染率,且HPV感染与宫颈癌的发病有着密切的联系。OBJECTIVE To explore the relationship between the human papillomavirus（HPV）infections and cervical cancer so as to provide guidance for clinical prevention of cervical cancer.METHODS The cervical cancer tissue specimens were collected from 50 patients who underwent cervical cancer biopsy or radical hysterectomy in the hospital from Jan 2012 to Dec 2014 and were assigned as the study group;the cervical tissue specimens were collected from 50 patients who underwent the hysteromyomectomy and were set as the control group.The prevalence of HPV infections in the two types of specimens was detected by using immunohistochemical staining method,the correlation between the HPV infection and the clinical characteristics of cervical cancer was analyzed,and the statistical analysis of data was performed with the use of SPSS19.0software.RESULTS The incidence rate of HPV infection of the study group was 46.0%,significantly higher than 4.0% of the control group（P〈0.05）.The analysis of the relationship between the HPV infection and the characteristics of cervical cancer showed that the incidence rate of HPV infection was 66.7%in the patients without amenorrhea,significantly higher than 15.0%in the patients with amenorrhea;the incidence rate of HPV infection of the clinical stage Ⅱ patients was 87.5%,significantly higher than 26.5% of the clinical stage Ⅰ patients;the incidence rate of HPV infection of the patients with lymph node metastasis was 83.3%,significantly higher than 25.0% of the patients without lymph node metastasis;the incidence rate of HPV infection of the patients with pathological histological grade 3 was80.0%,significantly higher than 30.0% of the patients with pathological histological grade 1and 40.0% of the patients with pathological histological grade 2（P〈0.05）.CONCLUSION The incidence rare of HPV infection is high in the patients with cervical cancer,and the HPV infection is closely associated with the cervical cancer.

关 键 词：宫颈癌 人乳头状瘤病毒 相关性 

分 类 号：R719[医药卫生—妇产科学]