延效中药薄荷驱蚊剂的制备  

Preparation of Chinese medicine peppermint long-acting mosquito repellents

作　　者：苏华丽[1] 张艳[2] 吴俊洪[2] 姚剑超 王利胜[2] 

机构地区：[1]肇庆市第一人民医院药学部,肇庆526020 [2]广州中医药大学中药学院,广州510006

出　　处：《北方药学》2016年第3期109-111,共3页Journal of North Pharmacy

基　　金：广东省肇庆市科技创新计划项目;No.2013E251

摘　　要：目的:制备延效无毒的中药薄荷驱蚊剂。方法:以薄荷油和猫薄荷油为驱蚊有效成分,以释放系数为评价指标,采用单因素试验筛选驱蚊剂各种辅料,正交试验考察辅料用量。结果:驱蚊剂的处方组成为溶剂40%乙醇溶液88.37%,缓释材料(聚丙烯酸树脂-聚维酮K90=2∶8)3.68%,主药(薄荷油-猫薄荷油=1∶1)4.42%,增溶剂吐温-80 3.53%。结论:本实验将缓释技术和高效液相法应用于驱避剂的制备,为天然植物类相关产品的研制与开发提供了参考。Objective：To prepare non-toxic long-acting mosquito repellents containing peppermint oil. Methods： The mosquito repellent＇s active ingredients are peppermint oil and cat mint oil with the release coefficient as the evaluation index. Adopting single factor test to filter all kinds of excipients; using orthogonal test to investigate the dosage of the excipients. Results： The prescription of mosquito repellent containing 88.37% solvent solution of 40% ethanol,3.68%sustained-release material（polyacrylate resin / Povidone K90=2∶8）,4.42%main drugs（peppermint oil/cat mint oil = 1∶1）,and 3.53% solubilizing agent Tween-80. Conclusions： In this study,applying sustained-release technology and HPLC to the preparation of mosquito repellent,this provided a reference for the research and development of natural plant-based products.

关 键 词：薄荷油 猫薄荷油 缓释驱蚊剂 高效液相色谱法 

分 类 号：R284[医药卫生—中药学]