某院2012～2013年鲍曼不动杆菌的临床分布及耐药菌分析  

Analysis of antibiotic resistance of strains baumannii and clinical distribution in a hospital from 2012 to 2013

作　　者：魏怡雯[1] 邱菡[1] 

机构地区：[1]深圳市第二人民医院,深圳518035

出　　处：《北方药学》2016年第3期161-162,共2页Journal of North Pharmacy

摘　　要：目的：了解鲍曼不动杆菌感染现状,分析其耐药谱变迁,动态监测其耐药性及发展趋势,为临床各科室控制感染及合理应用抗菌药物提供依据。方法：用VITEK2鉴定系统对菌株进行鉴定及药敏试验。用WHONET5.5软件对药敏结果进行统计学分析。结果：2012~2013年临床标本中分离的405株鲍曼不动杆菌主要分布在重症医学科（ICU）、呼吸科、神经外科、泌尿外科,其中ICU分布最多,占20.5%（83/405）,其次是呼吸科,占10.6%（43/405）,神经外科占7.6%（31/405）,泌尿外科占7.4%。在送检标本中,Ab的检出率以痰标本最高为37.3%,尿液、呼吸道分泌物、血液、脓液标本鲍曼不动杆菌的检出率分别为19.7%、16.1%、9.4%、8.4%,其余标本检出率为9.1%。头孢唑啉、头孢曲松、呋喃妥因的耐药率均达到100%,对头孢替坦、氨曲南的耐药率分别为99.1%、96.9%,左旋氧氟沙星耐药率较低,为23.1%;头孢哌酮耐药率最低,仅为6.9%。2012~2013年本院监测的抗生素耐药性有逐步升高的趋势,特别是鲍曼不动杆菌对碳青霉烯类耐药率增加迅速,重症监护室病房鲍曼不动杆菌对亚胺培南耐药率达80.1%。结论：鲍曼不动杆菌耐药性日趋严重,应引起临床科室以及医院感染科室的高度重视。Objective：Understanding of acinetobacter baumannii infection status,analyze the changes of drug resistance of dynamic monitoring the drug resistance and developing trend of clinical infection control department and provide evidence for reasonable application of antimicrobial agents. Methods：With VITEK2 identification system for identification and drug sensitive test strains.With WHONET5.5 software with the result of drug susceptibility for statistical analysis. Result：Between 2012 and 2013,405 strains of Acinetobacter Bauman were isolated from clinical specimens,which mainly distributed in the critical care,pediatric and severe medicine,general surgery,and the distribution of ICU was up to 20.5%（83/405）,followed by NICU,accounting for 10.6%（43/405）,7.6%（31/405）. In the specimens,AB detection rate in sputum samples were the highest for 37.3%,urine,secretions,blood,pus fluid specimens Bowman Acinetobacter the detection rates were 19.7%,16.1%,9.4%,8.4% and the rest of the specimen detection rate was9.1%. Cefazolin,ceftriaxone and nitrofurantoin resistance due to the rate reached 100%,ceftriaxone for Tanzania,aztreonam resistant rate were 99.1% and 96.9% and levofloxacin resistance rate is low,23.1%; cefoperazone drug resistance rate was lowest,only 6.9%.2012 ~2013 monitoring antibiotic resistance increasing trend,especially in 2013 rise is more significant,especially Acinetobacter baumannii in carbapenem resistant rate increased rapidly and the intensive care ward Bowman real bacilli to imipenem resistant rate was80.1%. Conclusion：Acinetobacter baumannii resistance has become increasingly serious,should cause clinical departments and hospital infection department attaches great importance to.

关 键 词：鲍曼不动杆菌 分离率 耐药性 

分 类 号：R446.5[医药卫生—诊断学]