NGAL、KIM-1和IL-18在急性肾损伤患儿诊断中的意义  

Significance of NGAL,KIM- 1 and IL- 18 in diagnosis of acute kidney injury in children

作　　者：王蓬伟[1] 周雅芮[1] 苏永红[1] 于加海[1] 

机构地区：[1]山东省潍坊市妇幼保健院,山东潍坊261011

出　　处：《中国民康医学》2016年第4期1-3,23,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:分析探讨尿液中中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、肾损伤分子-1(KIM-1)和白细胞介素-18(IL-18)在儿童急性肾损伤(AKI)诊断中的意义。方法:选取急性肾损伤患儿100例,并按照AKI诊断标准分为AKI组和非AKI组,每组各50例;另外选取正常小儿50例作为对照组。对3组研究对象的尿NGAL、KIM-1和IL-18,与血清肌酐(SCr)进行相关性研究分析,探讨以上3项指标在儿童急性肾损伤诊断中的应用价值。结果:1在SCr未发生明显变化前,AKI组患儿的3种因子水平均已升高,且尿NGAL升高最快(P<0.05);非AKI组和对照组研究对象的3种因子水平无明显改变(P>0.05)。2与非AKI组、对照组相比,AKI组患儿1期、2期、3期尿NGAL、IL-18、KIM-1和SCr的水平逐渐升高(P<0.05)。3AKI组患儿尿NGAL、IL-18和KIM-1均与SCr呈正相关(r=0.607、0.428、0.477,P均<0.05)。结论:AKI患儿进展过程中,尿NGAL、IL-18和KIM-1等3因子的水平均明显升高,且与SCr值及AKI严重程度呈正相关。尿NGAL、IL-18和KIM-1可作为早期儿童急性肾损伤诊断的生物标志因子。Objective： To analyze and discuss significance of urine neutrophil gelatinase- associated lipocalin（ NGAL）,kidney injury molecule- 1（ KIM- 1） and interleukin- 18（ IL- 18） in diagnosis of children with acute kidney injury（ AKI）. Methods： 100 children with AKI were selected and divided into AKI group and non AKI group（ 50 cases in each group）,while 50 cases of normal children were selected as control group. These children＇s urinary NGAL,KIM- 1 and IL- 18 levels were studied,and their correlations with serum creatinine（ SCr） were analyzed. Further,the application value of 3 indexes in the diagnosis of children with AKI was explored. Results：（ 1） Before the SCr level changed obviously,the levels of the 3 factors had increased,and urinary NGAL increased the fastest（ P〈0. 05）; the levels of the 3 factors in non AKI group and control group had no significant change（ P〉0. 05）.（ 2） Compared with non AKI group and control group,the levels of first-,second-,and third- stage urine NGAL,IL- 18,KIM-1 and SCrincreased gradually（ P〈0. 05）.（ 3） In AKI group,the urinary NGAL,IL- 18 and KIM- 1 were positively correlated with SCr（ r = 0. 607,0. 428,0. 477,all P〈0. 05）. Conclusions： During the progression of AKI,urine NGAL,IL- 18 and KIM- 1 3levels significantly increase,and are positively related to SCr and the severity of AKI. Urine NGAL,IL- 18 and KIM- 1 can be used as the biomarker factors for the early diagnosis of children with acute kidney injury.

关 键 词：中性粒细胞明胶酶相关脂质运载蛋白 白细胞介素-18 肾损伤分子-1 急性肾损伤 儿童 

分 类 号：R692[医药卫生—泌尿科学]