HCV感染与特异性T淋巴细胞免疫  

HCV infection and specific T lymphocyte immunity

作　　者：史继静[1] 张纪元[2] 张学秀[1] 王福生[1,2] 

机构地区：[1]北京大学解放军302医院教学医院感染性疾病诊疗与研究中心,100039 [2]解放军302医院感染性疾病诊疗与研究中心,北京100039

出　　处：《中华肝脏病杂志》2016年第3期170-174,共5页Chinese Journal of Hepatology

摘　　要：适应性免疫尤其是T淋巴细胞介导的细胞免疫在机体抗HCV感染中具有重要作用.病毒的清除需要强烈、持久、多表位的HCV特异性T淋巴细胞应答,后者功能障碍是导致感染慢性化的主要因素,有效的抗HCV治疗可在一定程度上恢复特异性T淋巴细胞功能.现就HCV感染不同转归时机体HCV特异性T淋巴细胞免疫应答的特点及机制进行讨论.Adaptive immunity,especially the cellular immunity mediated by T lymphocytes,plays an important role in the body＆#39;s fight against hepatitis C virus （HCV） infection.The clearance of HCV requires a strong,sustained,and multi-epitope response from specific T lymphocytes,and the dysfunction of specific T lymphocytes is the major reason for chronic infection.Effective treatment can restore the function of specific T lymphocytes to a certain extent.This article reviews the features and related mechanisms of immune response from specific T lymphocytes when the prognosis of patients with HCV infection is different.

关 键 词：T淋巴细胞 免疫 肝炎病毒 丙型 

分 类 号：R512.63[医药卫生—内科学]