3D打印技术应用于脊柱个性化椎体定制的实验研究  

Experimental study on application of 3D printing technology to print personalized vertebral body

作　　者：夏晓龙 陈扬[1] 邱奕雁[1] 杨欣建[1] 张伟彬[1] 杨泽雨[1] 

机构地区：[1]深圳市第二人民医院脊柱外科,广东518029

出　　处：《中国骨与关节损伤杂志》2016年第3期247-250,共4页Chinese Journal of Bone and Joint Injury

基　　金：深圳市科技计划项目(CXZZ20140414170821148);深圳市卫生计生系统科研项目(201401016)

摘　　要：目的阐述应用3D打印技术制作猪脊柱个性化椎体的过程,探讨3D打印技术在脊柱外科应用的可行性,并为进一步进行人工椎体的生物相容性与生物力学性能测试提供实体。方法通过对20头紫金蓝塘草猪的腰椎进行连续断层CT影像采集,获得猪腰椎DICOM影像数据,将所获得的影响数据导入MIMICS软件中,并应用该软件对断面影像进行修补和擦除,得到满意的3D图像,并以STL格式保存,应用Solid Works软件优化设计具有不同孔隙大小、孔隙率等特征的复杂多孔结构,再通过选择性激光熔化(SLM)技术打印出最终的人工椎体。然后,手术取出猪的整个7节腰椎,并将对应节段置换成人工椎体。观察人工椎体与猪脊柱椎体形态差异及椎体置换后整个腰椎形态变化。结果通过3D打印的人工椎体与手术取出的猪的相应节段椎体形态结构完全相符,置换后脊柱形态与术前未发生明显变化。结论应用3D打印技术能够实现复杂结构的椎体个性化制作,为被破坏的椎体实现个性化人工椎体置换提供新的思路。Objective To explore the production process by employing 3D printing technology to print personalized artificial vertebral spine, and to elucidate the feasibility of application of 3D printing technology in spinal surgery, and to provide the entity for further artificial vertebral body biocompatible and biomechanical test. Methods Lumbar vertebrae of 20 Zijin Lantang Grass Pig were scanned by Computer Tomography in a row. DICOM image data were obtained. The DICOM data were imported into the MIMICS software by which to repair and erase cross section image, to get a satisfactory 3D images. The data were saved in STL format. SelidWorks software optimization was employed to design different pore sizes and porosities of complex porous structure, to print out the final artificial vertebral body by SLM technology. Finally, the whole 7 lumbar vertebrae in the pig were replaced by the artificial vertebral body. Results The morphology of the 3D printing artificial vertebral body was in consistent with the real one. The whole spine morphology was not changed after replacement. Conclusion 3D printing technology makes it easy to print the individualized artificial vertebral body. This new technique provides new ideas for solution of the realization of personalized artificial vertebral body for replacement of destructed ones by any causes.

关 键 词：3D打印技术 人工椎体 选择性激光熔化 蜂窝状 

分 类 号：R687.3[医药卫生—骨科学]