Two new ortho benzoquinones from Uncaria rhynchophylla  

作　　者：ZHANG Qian CHEN Lei HU Le-Jian LIU Wen-Yuan FENG Feng QU Wei 

机构地区：[1]Department of Natural Medicinal Chemistry, China Pharmaceutical University [2]Department of Pharmaceutical Analysis, China Pharmaceutical University [3]Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University

出　　处：《Chinese Journal of Natural Medicines》2016年第3期232-235,共4页中国天然药物（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.81373956 and 81274064);the Priority Academic Program Development of Jiangsu Higher Education Institutions

摘　　要：The present study was designed to determine the chemical constituents of the stems and hooks of Uncaria rhynchophylla. The chemical constituents were isolated and purified from CH_2Cl_2 fraction by chromatography. Their structures were elucidated by spectroscopic analyses. Their cytotoxicity was tested using MTT method. Two new ortho benzoquinones, 3-diethylamino-5-methoxy-1, 2-benzoquinone(1) and 3-ethylamino-5-methoxy-1, 2-benzoquinone(2), together with a known compound isorhynchophyllic acid(3) were isolated from U. rhynchophylla. These compounds were evaluated for their cytotoxicity against cancer cells A549, Hep G2 and A2780. Compounds 1 and 2 were new ortho benzoquinones and showed weak antiproliferative activities on A549, Hep G2 and A2780 cells. Compound 3 significantly inhibited the proliferation of A549, Hep G2 and A2780 cells with IC_(50) values being 5.8, 12.8 and 11.8 μmol·L^(–1), respectively.The present study was designed to determine the chemical constituents of the stems and hooks of Uncaria rhynchophylla. The chemical constituents were isolated and purified from CH2C12 fraction by chromatography. Their structures were elucidated by spectroscopic analyses. Their cytotoxicity was tested using MTT method. Two new ortho benzoquinones, 3-diethylamino-5-methoxy-1, 2-banzoquinone （1） and 3-ethylamino-5-methoxy-1, 2-benzoquinone （2）, together with a known compound isorhynchophyllic acid （3） were isolated from U. rhynchophylla. These compounds were evaluated for their cytotoxicity against cancer cells A549, HepG2 and A2780. Compounds 1 and 2 were new ortho benzoquinones and showed weak antiproliferative activities on A549, HepG2 and A2780 cells. Compound 3 significantly inhibited the proliferation of A549, HepG2 and A2780 cells with ICs0 values being 5.8, 12.8 and 11.8 μmol.L-1, respectively.

关 键 词：Uncaria rhynchophylla Ortho benzoquinones Spectroscopic identification 

分 类 号：R284[医药卫生—中药学]