索他洛尔联合稳心颗粒对心动过速患者心率及血浆AngⅡ与VIP含量影响的研究  

Effect of Sotalol Combined with Wenxin Granule on Heart Rate and Plasma Ang II and VIP in Patients with Tachycardia

作　　者：王鹏[1] 姚光涛[1] 王莉 董宏伟[1] 张强[1] 李莹[1] 

机构地区：[1]德州市人民医院,山东德州253014 [2]禹城市人民医院,山东禹城251200

出　　处：《中华中医药学刊》2016年第3期763-766,共4页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:探讨索他洛尔联合稳心颗粒对心动过速患者心率及血浆血管紧张素Ⅱ(AngⅡ)与血管活性肠肽(VIP)含量的影响。方法:收集医院收治的阵发性室上性心动过速患者56例,随机分为对照组和实验组,每组各28例,对照组给予盐酸索他洛尔片口服治疗,实验组在对照组基础上给予稳心颗粒口服治疗,治疗周期为2周,治疗结束后,对所有患者的血浆AngⅡ、肾素(PRA)、醛固酮(ALD)、VIP含量、心率、心率变异性情况及临床疗效进行检测。结果:治疗后,与对照组比较,(1)实验组患者心率明显较低,差异具有统计学意义(P<0.05);(2)实验组患者的SDNN、r MSSD、PNN50水平较高,SDANN水平较低(P<0.05);(3)实验组患者血浆AngⅡ、PRA、ALD含量较低(P<0.05);(4)实验组患者血浆VIP水平较高(P<0.05);(5)实验组患者总有效率较高(P<0.05)。结论:索他洛尔联合稳心颗粒能够显著升高心动过速患者血浆VIP水平,降低血浆AngⅡ、PRA、ALD水平,降低心率以及心率变异性,临床疗效显著,对临床有指导意义。Objective： To analyze the effect of sotalol combined with Wenxin Granule on heart rate and plasma Vascular tension II（ Ang II） and vasoactive intestinal peptide（ VIP） in patients with tachycardia. Methods： 56 patients who were diagnosed as paroxysmal ventricular tachycardia in Dezhou People＇s Hospital of Traditional Chinese Medicine were collected. All patients were randomly divided into experimental group and control group,28 cases in each group,Patients in the control group were given hydrochloride sotalol tablets for oral treatment and the experimental group treated with Wenxin Granule orally on the basis of the treatment in control group. The treatment cycle was 2 weeks. At the end of treatment,all patients＇ plasma content of Ang II,plasma renin activity（ PRA）,aldosterone（ ALD） and VIP,heart rate,heart rate variability and clinical efficacy were detected. Results： After treatment,compared with control group：（1）the heart rate of the experimental group was significantly lower and the difference was statistically significant（ P〈0. 05）;（2）SDNN,PNN50 and r MSSD levels were higher in the experimental group and the SDANN level was lower（ P〈0. 05）;（3）the contents of Ang II,PRA and ALD in the experimental group were lower（ P〈0. 05）;（4）the plasma VIP level of experimental group was higher（ P〈0. 05）;（5）the patients in the experimental group had higher efficiency（ P〈0. 05）. Conclusions： Sotalol combined with Wenxin Granule can significantly increase the plasma VIP level in patients with tachycardia,reduce the levels of Ang II,ALD and PRA and reduce the heart rate and heart rate variability and has a significant clinical effect.

关 键 词：索他洛尔联合稳心颗粒 心动过速 AngⅡ VIP 

分 类 号：R541.7[医药卫生—心血管疾病]