A facile ＂ship-in-a-bottle＂ approach to construct nanorattles based on upconverting lanthanide-doped fluorides  

作　　者：Shan Lu Datao Tu Xingjun Li Renfu Li Xueyuan Chen 

机构地区：[1]Key Laboratory of Optoelectronic Materials Chemistry and Physics, and State Key Laboratory of Structural Chemistry, Fujian Instituteof Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China

出　　处：《Nano Research》2016年第1期187-197,共11页纳米研究（英文版）

基　　金：This work is supported by the National Basic Research Program of China （No. 2014CB845605）, Special Project of National Major Scientific Equipment Development of China （No. 2012YQ120060）, the National Natural Science Foundation of China （Nos. 21201163, 21401196, U1305244, and 21325104）, the CAS/SAFEA International Partnership Program for Creative Research Teams, and Strategic Priority Research Program of the CAS （No. XDA09030307）.

摘　　要：Rattle structure is a topic of great interest in design and application of nano- materials due to the unique core@void@shell architecture and the integration of functions. Herein, we developed a novel ＂ship-in-a-bottle＂ method to fabricate upconverting （UC） luminescent nanorattles by incorporating lanthanide-doped fluorides into hollow mesoporous silica. The size of nanorattles and the filling amount of fluorides can be well controlled. In addition, the modification of silica shell （with phenylene and amine groups） and the variation of efficient UC fluorides （NaYF4：Yb, Er, NaLuF4：Yb, Er, NaGdF4：Yb, Er and LiYF4：Yb, Er） were readily achieved. The resulting nanorattles exhibited a high capacity and pH-dependent release of the anti-cancer drug doxorubicin （DOX）. Furthermore, we employed these nanorattles in proof-of-concept UC-monitoring drug release by utilizing the energy transfer process from UC fluorides to DOX, thus revealing the great potential of the nanorattles as efficient cancer theranostic agent.Rattle structure is a topic of great interest in design and application of nano- materials due to the unique core@void@shell architecture and the integration of functions. Herein, we developed a novel ＂ship-in-a-bottle＂ method to fabricate upconverting （UC） luminescent nanorattles by incorporating lanthanide-doped fluorides into hollow mesoporous silica. The size of nanorattles and the filling amount of fluorides can be well controlled. In addition, the modification of silica shell （with phenylene and amine groups） and the variation of efficient UC fluorides （NaYF4：Yb, Er, NaLuF4：Yb, Er, NaGdF4：Yb, Er and LiYF4：Yb, Er） were readily achieved. The resulting nanorattles exhibited a high capacity and pH-dependent release of the anti-cancer drug doxorubicin （DOX）. Furthermore, we employed these nanorattles in proof-of-concept UC-monitoring drug release by utilizing the energy transfer process from UC fluorides to DOX, thus revealing the great potential of the nanorattles as efficient cancer theranostic agent.

关 键 词：nanorattle upconverting luminescence lanthanide-doped fluoride hollow mesoporous silica ORGANOSILICA drug release 

分 类 号：TQ460.4[化学工程—制药化工] TN244[电子电信—物理电子学]