15例坏疽性脓皮病临床分析  

Analysis of 15 cases with pyoderma gangrenosum

作　　者：丁媛[1] 路庆丽[1] 康晓静[1] 

机构地区：[1]新疆维吾尔自治区人民医院皮肤性病科,乌鲁木齐830002

出　　处：《实用皮肤病学杂志》2016年第1期15-17,共3页Journal of Practical Dermatology

摘　　要：目的为进一步了解坏疽性脓皮病的临床资料、组织病理特点及治疗方法。方法对15例坏疽性脓皮病(PG)患者进行回顾性分析。结果 15例确诊患者中男9例,女6例,男∶女为1.5∶1;溃疡型PG有10例(66.67%),并发的相关内科疾病有类风湿关节炎、溃疡性结肠炎、慢性乙型肝炎、肺部感染、重度贫血。对溃疡周围卫星灶非溃疡皮损行组织病理检查,发现明显的血管炎性组织病理改变。结论溃疡型PG为其主要临床类型,不同部位取材其组织病理表现不同,沙利度胺联合环磷酰胺治疗PG有效,且随访复发率较低。Objective To cognize pyoderma gangrenosum＇s（PG） characteristic clinical aspects, pathological characteristics and treatment methods. Methods A retrospective study were performed based on15 cases of PG during a 5-year period. Results A total of 15 patients were included, 6 women and 9 men, with a 1.5：1 F：M ratio. Ten cases（66.67%） were ulcerative variant. The underlying diseases were rheumatoid arthritis, ulcerative colitis, chronic hepatitis B, pneumonia, and severe anemia. Vasculitis was seen in the border of ulcer and satellite lesions without ulcer. Conclusion The ulcerative variant was the most frequent form of PG in our study, Pathological changes depend on the site from which a biopsy specimen is obtained in a given lesion. The therapy of thalidomide combined with cyclophosphamide is effective, which with lower recurrence rate.

关 键 词：脓皮病 坏疽性 临床分析 

分 类 号：R753.6[医药卫生—皮肤病学与性病学]