应用安全、有效、质量可控研究模式指导苦参总碱提取纯化工艺的优选  

Optimization of extraction and purification for alkaloids of Sophora flavescens by safe, effective and quality controllable research mode

作　　者：于喜水 苏慧[3] 李丽丽[4] 张颖 张也[3] 苏云明[3] 金哲雄[4] 

机构地区：[1]哈尔滨同君医药科技有限公司,哈尔滨150001 [2]黑龙江省食品药品审核查验中心,哈尔滨150090 [3]黑龙江中医药大学,哈尔滨150040 [4]哈尔滨商业大学,哈尔滨150078

出　　处：《中南药学》2016年第2期150-153,共4页Central South Pharmacy

基　　金：黑龙江省科技攻关项目(No.GB09C314):注射用苦参总碱(冻干)生产工艺、药效、毒性、质量标准相关性研究

摘　　要：目的探讨中药安全、有效、质量可控的研究方法。方法以苦参总碱提取纯化工艺为研究对象,采用安全、有效、质量可控的研究模式,指导其工艺的研究。结果筛选出药效高、毒性小、理化指标合理的工艺并制定与其相关的质量标准。结论证明采用该研究模式对指导中药工艺研究是可行的。Objective To determine the safe, effective, and quality-controllable research method for traditional Chinese medicine. Methods Alkaloids of Sophora flavescens was taken as the research objects, and a safe, effective and quality-controllable research mode was used. Results We screened the process, with high efficacy, small toxicity, and reasonable physicochemical indexes and establishied related quality standards. Conclusion This research mode is feasible for the process of traditional Chinese medicine.

关 键 词：苦参总碱 提取纯化工艺 安全、有效、质量可控研究模式 

分 类 号：R284[医药卫生—中药学] TQ461[医药卫生—中医学]