抵抗素与IL-6在妊娠期高血患者胎盘组织中的表达及临床意义  

Expression and significance of resistin and interleukin-6 in placenta tissue in patients with hypertensive disorders in pregnancy

作　　者：陈璐[1] 黄桓[2] 李盛[1] 

机构地区：[1]江汉大学附属医院妇产科,湖北武汉430015 [2]武汉大学医学院同仁医院妇产科,湖北武汉430074

出　　处：《中国妇幼健康研究》2016年第2期183-185,共3页Chinese Journal of Woman and Child Health Research

摘　　要：目的研究抵抗素与白细胞介素-6(IL-6)在妊娠期高血患者胎盘组织中的表达并探讨其临床意义。方法选取2013年6月至2014年10月在江汉大学附属医院妇产科分娩合并妊娠期高血压疾病的孕妇90例作为观察组,根据病情将其分为子痫前期轻度组和子痫前期重度组,每组45例,选取同期在江汉大学附属医院妇产科进行分娩的正常孕妇45例作为对照组,检测抵抗素和IL-6在所有研究对象胎盘组织中的表达。结果与对照组相比,抵抗素在子痫前期轻度组、重度组患者胎盘中表达阳性率明显升高,差异具有统计学意义(x_轻~2=4.11,P<0.05;x_重~2=13.52,P<0.05),IL-6在子痫前期轻度组、重度组患者胎盘中表达阳性率明显升高,差异具有统计学意义(x_轻~2=13.26,P<0.05;x_重~2=23.46,P<0.05);与子痫前期轻度组相比,抵抗素在子痫前期重度组患者胎盘中表达阳性率明显升高,差异具有统计学意义(x~=3.87,P<0.05),IL-6在子痫前期重度组患者胎盘中表达阳性率明显升高,差异具有统计学意义(x^2=4.41,P<0.05)。根据评分标准,与对照组相比,抵抗素在子痫前期轻度组、重度组患者胎盘组织中的表达明显升高,差异具有统计学意义(Uc_轻=3.28,P<0.05;Uc_重:5.47,P<0.05),IL-6在子痫前期轻度组、重度组患者胎盘组织中的表达明显升高,差异具有统计学意义(Uc_轻=4.34,P<0.05;Uc_重=6.17,P<0.05);与子痫前期轻度组相比,抵抗素在子痫前期重度组患者胎盘中表达程度明显升高,差异具有统计学意义(Uc=2.61,P<0.05),IL-6在子痫前期重度组患者胎盘中表达程度明显升高,差异具有统计学意义(Uc=1.99,P<0.05)。结论抵抗素与IL-6在妊娠期妇女胎盘组织中均有不同程度的表达,但在妊娠期高血压疾病患者胎盘组织中的表达较高,而且随着病情的加重,其表达水平逐渐增高,说明其水平的变化与疾病的严重程度有关,值得临床上进一步研究。Objective To study the expressions of resistin and interleukin-6 （ IL-6 ） in placenta tissue in patients with hypertensive disorders in pregnancy and discuss the clinical significance. Methods From June 2013 to October 2014, 90 patients delivering in Affiliated Hospital of Jianghan University with hypertensive disorders in pregnancy were chosen in observation group, and they were divided into mild preeclampsia group and severe preeclampsia group according to illness. There were 45 cases in both groups. Over the same period another 45 cases with normal pregnancy were selected in control group. The expressions of resistin and IL-6 in placenta tissue were detected. Results Compared with the control group, the positive expression rates of resistin elevated significantly in placenta tissues of mild preeclampsia group and severe preeclampsia group, and the differences were significant （X2 value was 4.11 and 13.52, respectively, both P 〈 O. 05 ）. The positive expression rate of IL-6 in placenta tissue of mild preeclampsia group and severe preeclampsia group elevated with significant difference （χ^2 value was 13.26 and 23.46, respectively, both P 〈 0.05）. Compared with the mild preeclampsia group, the positive expression rate of resistin and IL-6 in placenta tissue of severe preeclampsia group elevated significantly, and the differences were significant （χ^2 value was 3.87 and 4.41, respectively, both P 〈0.05 ）. According to score standard, the expression of resistin in placenta tissue of mild and severe preeclampsia groups increased significantly compared with the control group, and the differences had statistical significance （ Uc was 3.28 and 5.47, respectively, both P 〈 0.05 ）, so did the expression of IL-6 （ Uc was 4.34 and 6.17, respectively, both P 〈 0.05 ）. Compared with the mild preeclampsia group, the expression of resistin and IL-6 in placenta tissue of severe preeclampsia group enhanced significantly, and the differences were statistically significant （Uc was 2.61 and 1.9

关 键 词：抵抗素 白细胞介素-6 妊娠期高血压疾病 子痫前期 

分 类 号：R714.53[医药卫生—妇产科学]